Literature summary for 4.2.1.32 extracted from

Kim, O.B.; Reimann, J.; Lukas, H.; Schumacher, U.; Grimpo, J.; Duennwald, P.; Unden, G.
Regulation of tartrate metabolism by TtdR and relation to the DcuS-DcuR-regulated C4-dicarboxylate metabolism of Escherichia coli (2009), Microbiology, 155, 3632-3640.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of plasmid-encoded ttdA'-'lacZ	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Synonyms

Synonyms	Comment	Organism
L-Tartrate dehydratase	-	Escherichia coli
TtdA	-	Escherichia coli

Expression

Organism	Comment	Expression
Escherichia coli	expression of ttdA is repressed by O2 in an FNR-dependent manner. Presence of nitrate strongly represses ttdA. When glucose is present in addition to L-tartrate, expression of ttdA'-'lacZ is decreased to 24% of the L-tartrate-induced state	down
Escherichia coli	expression of plasmid-encoded ttdA'-'lacZ is stimulated to a high level (64fold) by L-tartrate during anaerobic growth. meso-Tartrate causes slightly lower (47.5fold) induction. During aerobic growth, expression of ttdA'-'lacZ is very low in the presence or absence of L-tartrate, and it increases by a factor of about 220 under anaerobic conditions. Expression of ttdA requires transcriptional activation by fumarate nitrate reductase regulator (FNR), which is in the active state only under anaerobic conditions	up

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Release 2023.1 (January 2023)