Literature summary for 4.2.1.30 extracted from

Sandala, G.M.; Kovacevic, B.; Baric, D.; Smith, D.M.; Radom, L.
On the reaction of glycerol dehydratase with but-3-ene-1,2-diol (2009), Chemistry, 15, 4865-4873.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-but-3-ene-1,2-diol	irreversibly inactivates. Time-dependent inhibition of GDH to yield a complex that is spectroscopically (EPR) active. Presence of the 1,2-dihydroxybut-3-en-1-yl radical in the reaction, which has relatively high energy	Citrobacter freundii

Organism

Organism	UniProt	Comment	Textmining
Citrobacter freundii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glycerol	reaction possesses modest H-transfer barriers of 43-57 KJ/mol. Barrier to rearrangement is 116.8 KJ/mol	Citrobacter freundii	3-hydroxypropanal + H2O	-	?

Synonyms

Synonyms	Comment	Organism
B12-dependent enzyme glycerol dehydratase	-	Citrobacter freundii
GDH	-	Citrobacter freundii
glycerol dehydratase	-	Citrobacter freundii

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Release 2023.1 (January 2023)