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Literature summary for 4.2.1.30 extracted from
- Characterization and mechanism of action of a reactivating factor for adenosylcobalamin-dependent glycerol dehydratase (2001), J. Biol. Chem., 276, 36514-36519.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GdrA protein | recombinant GdrA and GdrB proteins form a tight complex of (GdrA)2(GdrB)2, which reactivates the glycerol- or O2-inactivated enzyme as well as the as the enzyme-cyanocobalamin complex in the presence of ATP, Mg2+ and adenosylcobalamin | Klebsiella pneumoniae | |
| GdrB protein | recombinant GdrA and GdrB proteins form a tight complex of (GdrA)2(GdrB)2, which reactivates the glycerol- or O2-inactivated enzyme as well as the as the enzyme-cyanocobalamin complex in the presence of ATP, Mg2+ and adenosylcobalamin | Klebsiella pneumoniae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol | - |
Klebsiella pneumoniae |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | Klebsiella pneumoniae | - |
3-hydroxypropanal + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella pneumoniae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | - |
Klebsiella pneumoniae | 3-hydroxypropanal + H2O | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| adenosylcobalamin | dependent | Klebsiella pneumoniae | |
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