Literature summary for 4.2.1.3 extracted from

Michta, E.; Ding, W.; Zhu, S.; Blin, K.; Ruan, H.; Wang, R.; Wohlleben, W.; Mast, Y.
Proteomic approach to reveal the regulatory function of aconitase AcnA in oxidative stress response in the antibiotic producer Streptomyces viridochromogenes Tue494 (2014), PLoS ONE, 9, e87905 .

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces viridochromogenes	Q9RIL1	under iron-sufficiency conditions, AcnA functions as an enzyme of the tricarboxylic acid cycle, whereas under iron depletion it is a regulator of iron metabolism and oxidative stress response	-
Streptomyces viridochromogenes Tue494	Q9RIL1	under iron-sufficiency conditions, AcnA functions as an enzyme of the tricarboxylic acid cycle, whereas under iron depletion it is a regulator of iron metabolism and oxidative stress response	-

General Information

General Information	Comment	Organism
physiological function	a comparative proteomic approach with the wild-type and the AcnA mutant strain under oxidative stress conditions identifies up to 90 differentially expressed proteins in both strains. Some of the respective target mRNAs show the presence of iron responsive element motifs. Aconitase controls translation elongation factor Tu expression upon oxidative stress and may be directly involved in regulation upon oxidative stress	Streptomyces viridochromogenes

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Release 2023.1 (January 2023)