Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P19414 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Aco1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | a zinc hyper-tolerant deletion mutant, which lacks the Pif1 DNA helicase, shows increased iron accumulation, redistribution of the aconitase protein to mitochondria, and also a loss of aconitase activity, despite normal Aco1 protein levels being present. Lack of Aco1 enzymatic activity in mitochondria, citrate accumulation and lack of activity of [Fe-S] enzymes, e.g. succinate dehydrogenase, appear to be direct molecular indicators of increased zinc tolerance | Saccharomyces cerevisiae |