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Literature summary for 4.2.1.3 extracted from

  • Guirola, M.; Jimenez-Marti, E.; Atrian, S.
    On the molecular relationships between high-zinc tolerance and aconitase (Aco1) in Saccharomyces cerevisiae (2014), Metallomics, 6, 634-645 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P19414
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Synonyms

Synonyms Comment Organism
Aco1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function a zinc hyper-tolerant deletion mutant, which lacks the Pif1 DNA helicase, shows increased iron accumulation, redistribution of the aconitase protein to mitochondria, and also a loss of aconitase activity, despite normal Aco1 protein levels being present. Lack of Aco1 enzymatic activity in mitochondria, citrate accumulation and lack of activity of [Fe-S] enzymes, e.g. succinate dehydrogenase, appear to be direct molecular indicators of increased zinc tolerance Saccharomyces cerevisiae