Literature summary for 4.2.1.3 extracted from

Crooks, D.R.; Ghosh, M.C.; Braun-Sommargren, M.; Rouault, T.A.; Smith, D.R.
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells (2007), J. Neurosci. Res., 85, 1797-1809.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Mn2+	inhibition of enzyme, resulting in up to 90% increase in intracellular citrate. Mitochondrial isoform is significantly more sensitive to Mn2+ than cytosolic isoform. Inhibition leads to conversion of enzyme to iron regulatory protein IRP 1 and increases the abundance of IRP2, leading to reduced H-ferritin expression, inreased transferrin receptor expression, and increased uptake of transferrin. IRP2 has a dominant role in Mn2+-induced alteration of iron homeostasis over aconitase/IRP1	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	cytosolic isoform	Rattus norvegicus	5829	-
mitochondrion	mitochondrial isoform	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AF5 cell	mesencephalic-derived cell line	Rattus norvegicus	-

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Release 2023.1 (January 2023)