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Literature summary for 4.2.1.24 extracted from

  • Vargas, L.M.; Soares, M.B.; Izaguirry, A.P.; Luedtke, D.S.; Braga, H.C.; Savegnago, L.; Wollenhaupt, S.; Brum, D.d.o.s..S.; Leivas, F.G.; Santos, F.W.
    Cadmium inhibits the ovary delta-aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno-furanoside (2013), J. Appl. Toxicol., 33, 679-684.
    View publication on PubMed
Search for more literature for 4.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ 0.1 mM Cd2+ totally inhibits enzyme activity. Dithiothreitol (0.003 mM) is able to restore the inhibition of enzyme activity caused by Cd2+ (0.02 mM) Mus musculus
additional information not inhibited by Seleno-furanoside Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required for activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-aminolevulinate Mus musculus
-
 porphobilinogen + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminolevulinate
-
 Mus musculus porphobilinogen + H2O
-
 ?

Synonyms

Synonyms Comment Organism
delta-ALA-D
-
 Mus musculus
delta-aminolevulinate dehydratase
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01917
-
 at pH 6.8 and 37°C Mus musculus Cd2+