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Literature summary for 4.2.1.24 extracted from

  • Jaffe, E.K.
    The porphobilinogen synthase family of metalloenzymes (2000), Acta Crystallogr. Sect. D, 56, 115-128.
    View publication on PubMed
Search for more literature for 4.2.1.24

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Saccharomyces cerevisiae
-
 Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Pseudomonas aeruginosa
Mg2+ 4 Zn at metal binding site A and 8 Mg at metal binding site C are required for full activity per homooctamer Pisum sativum
Mg2+ 4 Zn at metal binding site A , 4 Zn at metal binding site B and 8 Mg at metal binding site C are required for full activity per homooctamer Escherichia coli
Zinc 4 Zn at metal binding site A and 8 Mg at metal binding site C are required for full activity per homooctamer Pisum sativum
Zinc 4 Zn at metal binding site A , 4 Zn at metal binding site B and 8 Mg at metal binding site C are required for full activity per homooctamer Escherichia coli
Zinc 4 Zn at metal binding site A and 4 Zn at metal binding site B are required for full activity per homooctamer Homo sapiens
Zinc 8 Zn at metal binding site A and 8 Zn at metal binding site B are required for full activity per homooctamer Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-aminolevulinate Homo sapiens
-
 ?
-
 ?
5-aminolevulinate Pseudomonas aeruginosa enzyme catalyzes the first common step in tetrapyrrole biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Actinobacillus sp.
-
-
-
Aquifex sp.
-
-
-
Archaeoglobus sp.
-
-
-
Bordetella sp.
-
-
-
Bradyrhizobium sp.
-
-
-
Campylobacter sp.
-
-
-
Candida sp. (in: Saccharomycetales)
-
-
-
Caulobacter sp.
-
-
-
Chlamydia sp.
-
-
-
Chlamydomonas sp.
-
-
-
Clostridium sp.
-
-
-
Deinococcus sp.
-
-
-
Escherichia coli
-
-
-
Helicobacter sp.
-
-
-
Homo sapiens
-
-
-
Methanobacterium sp.
-
-
-
Methanococcus sp.
-
-
-
Methanothermus sp.
-
-
-
Mycobacterium sp.
-
-
-
Neisseria sp.
-
-
-
Physcomitrella sp.
-
-
-
Pisum sativum
-
-
-
Propionibacterium sp.
-
-
-
Pseudomonas aeruginosa Q59643
-
-
Rattus norvegicus
-
-
-
Rhodobacter sp.
-
-
-
Rickettsia sp.
-
-
-
Saccharomyces cerevisiae P05373
-
-
Salmonella sp.
-
-
-
Schizosaccharomyces sp.
-
-
-
Shewanella sp.
-
-
-
Streptomyces sp.
-
-
-
Synechocystis sp.
-
-
-
Vibrio sp.
-
-
-
Yersinia sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 5-aminolevulinate = porphobilinogen + 2 H2O mechanism Pseudomonas aeruginosa
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminolevulinate
-
 Homo sapiens ?
-
 ?
5-aminolevulinate enzyme catalyzes the first common step in tetrapyrrole biosynthesis Pseudomonas aeruginosa ?
-
 ?