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Literature summary for 4.2.1.24 extracted from
- delta-Aminolevulinic acid dehydratase of Mycobacterium phlei (1971), Biochim. Biophys. Acta, 227, 698-705.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxy-4-oxo-L-norvaline | competitive | Mycolicibacterium phlei |  |
| 5-hydroxylevulinate | competitive | Mycolicibacterium phlei | |
| EDTA | - |
Mycolicibacterium phlei | |
| K2SO4 | slight | Mycolicibacterium phlei | |
| levulinic acid | competitive | Mycolicibacterium phlei | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.077 | - |
5-aminolevulinate | - |
Mycolicibacterium phlei | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mycolicibacterium phlei | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycolicibacterium phlei | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycolicibacterium phlei |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mycolicibacterium phlei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminolevulinate + 5-aminolevulinate | - |
Mycolicibacterium phlei | porphobilinogen + 2 H2O | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.2 | - |
- |
Mycolicibacterium phlei |
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Release 2023.1 (January 2023)
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