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Literature summary for 4.2.1.24 extracted from
- Beef-liver 5-aminolevulinic acid dehydratase (1972), Eur. J. Biochem., 29, 563-671.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thiol | required | Bos taurus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | inhibition at low concentration of substrate and stimulation at high levels of substrate | Bos taurus | |
| EDTA | - |
Bos taurus | |
| iodoacetamide | 1 mM, 97% inhibition | Bos taurus | |
| NEM | 1 mM, 85% inhibition | Bos taurus | |
| Pb2+ | - |
Bos taurus | |
| PCMB | 1 mM, 97% inhibition | Bos taurus | |
| Zn2+ | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
5-aminolevulinate | partially purified enzyme | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | inhibition at low concentration of substrate and stimulation at high levels of substrate | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 260000 | - |
low-speed equilibrium sedimentation | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminolevulinate + 5-aminolevulinate | - |
Bos taurus | porphobilinogen + 2 H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
- |
Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 64 | - |
60 min, 20% loss of activity | Bos taurus |
| 80 | - |
15 min, 50% loss of activity | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | - |
- |
Bos taurus |
| 6.3 | 6.4 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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