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Literature summary for 4.2.1.22 extracted from

  • Carballal, S.; Cuevasanta, E.; Yadav, P.K.; Gherasim, C.; Ballou, D.P.; Alvarez, B.; Banerjee, R.
    Kinetics of nitrite reduction and peroxynitrite formation by ferrous heme in human cystathionine beta-synthase (2016), J. Biol. Chem., 291, 8004-8013 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P35520
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Cofactor

Cofactor Comment Organism Structure
heme enzyme possesses a noncatalytic heme cofactor with cysteine and histidine as ligands. Nitrite is reduced by Fe(II)-CBS to form Fe(II)NO radical-CBS. Reoxidation of Fe(II)NO radical-CBS by O2 shows complex kinetic behavior and leads to peroxynitrite (ONOO-) formation Homo sapiens