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Literature summary for 4.2.1.22 extracted from

  • Hirata, Y.; Funato, Y.; Takano, Y.; Miki, H.
    Mg2+-dependent interactions of ATP with the cystathionine-beta-synthase (CBS) domains of a magnesium transporter (2014), J. Biol. Chem., 289, 14731-14739 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
T568I substitution of amino acid residue in the CBS domains of CNNM2, abrogates Mg2+ efflux and binding of ATP Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q3TWN3
-
-

Synonyms

Synonyms Comment Organism
CNNM2
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Mus musculus

General Information

General Information Comment Organism
physiological function deletion mutants of conserved domain protein/cyclin M Mg2+ transporter CNNM2, lacking the CBS domains, are unable to promote Mg2+ efflux. The CBS domains of CNNM2 bind to ATP in a Mg2+-dependent manner Mus musculus