Literature summary for 4.2.1.22 extracted from

Pey, A.L.; Majtan, T.; Kraus, J.P.
The role of surface electrostatics on the stability, function and regulation of human cystathionine beta-synthase, a complex multidomain and oligomeric protein (2014), Biochim. Biophys. Acta, 1844, 1453-1462 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
role of surface electrostatics. The kinetic stability of the catalytic and regulatory domains is significantly affected by the modulation of surface electrostatics through noticeable structural and energetic changes along their denaturation pathways. Surface electrostatics strongly affect SAM binding properties to those sites responsible for either enzyme activation or kinetic stabilization	Homo sapiens

General Stability

General Stability	Organism
in the presence of 200 mM NaCl the kinetic stability of the regulatory domains is increased about 300fold while the stability of catalytic domains decreases about 5fold	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35520	-	-

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Release 2023.1 (January 2023)