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Literature summary for 4.2.1.22 extracted from

  • Bhattacharyya, S.; Saha, S.; Giri, K.; Lanza, I.R.; Nair, K.S.; Jennings, N.B.; Rodriguez-Aguayo, C.; Lopez-Berestein, G.; Basal, E.; Weaver, A.L.; Visscher, D.W.; Cliby, W.; Sood, A.K.; Bhattacharya, R.; Mukherjee, P.
    Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance (2013), PLoS ONE, 8, e79167.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + L-homocysteine Homo sapiens
-
 L-cystathionine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
 Homo sapiens
-
A-2780/CP-70 cell
-
 Homo sapiens
-
epithelial ovarian cancer cell
-
 Homo sapiens
-
OV-202 cell
-
 Homo sapiens
-
ovarian carcinoma cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CBS
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is overexpressed in primary epithelial ovarian cancer and ovarian cancer cell lines up

General Information

General Information Comment Organism
physiological function cystathionine beta-synthase contributes to advanced ovarian cancer progression and drug resistance. The enzyme also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial reactive oxygen species production, oxygen consumption and ATP generation Homo sapiens