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Literature summary for 4.2.1.22 extracted from

  • Wang, L.; Jhee, K.H.; Hua, X.; DiBello, P.M.; Jacobsen, D.W.; Kruger, W.D.
    Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice (2004), Circ. Res., 94, 1318-1324.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice that contain the human cystathionine beta-synthase cDNA under control of the zinc-inducible metallothionein promoter (Tg-CBS). In the presence of zinc, Tg-CBS mice have a 2fold to 4fold increase in liver and kidney cystathionine beta-synthase activity compared with nontransgenic littermates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens elevated total plasma homocysteine is an independent risk factor in the development of vascular disease in humans. Elevating cystathionine beta-synthase level is an effective method to lower plasma homocysteine levels ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information elevated total plasma homocysteine is an independent risk factor in the development of vascular disease in humans. Elevating cystathionine beta-synthase level is an effective method to lower plasma homocysteine levels Homo sapiens ?
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