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Literature summary for 4.2.1.20 extracted from

  • Miles, E.W.
    The tryptophan synthase alpha2beta2 complex: a model for substrate channeling, allosteric communication, and pyridoxal phosphate catalysis (2013), J. Biol. Chem., 288, 10084-10091.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2,3-dihydro-L-tryptophan very good competitive inhibitor Salmonella enterica subsp. enterica serovar Typhimurium
oxindolyl-L-alanine very good competitive inhibitor Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate Salmonella enterica subsp. enterica serovar Typhimurium overall reaction L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-dihydro-5-fluoro-L-tryptophan isomerization Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
5-fluoro-L-tryptophan isomerization Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
indole-3-glycerol phosphate reaction catalyzed by the alpha subunit Salmonella enterica subsp. enterica serovar Typhimurium indole + D-glyceraldehyde 3-phosphate
-
r
L-Ser + indole reaction catalyzed by the beta subunit Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + H2O
-
ir
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate overall reaction Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
-
?

Subunits

Subunits Comment Organism
heterotetramer
-
Salmonella enterica subsp. enterica serovar Typhimurium