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Literature summary for 4.2.1.20 extracted from

  • Mozzarelli, A.; Peracchi, A.; Rossi, G.; Ahmed, S.; Miles, E.
    Microspectrophotometric studies on single crystals of the tryptophan synthase alpha 2 beta 2 complex demonstrate formation of enzyme-substrate intermediates (1989), J. Biol. Chem., 264, 15774-15780.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method, using 1 mM dithiothreitol, 0.04% (w/v) NaN3, and 12% (w/v) polyethylene glycol 8000 Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(indol-3-yl)glycerol 3-phosphate + L-serine alpha reaction Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
-
r
L-serine + indole beta reaction Salmonella enterica subsp. enterica serovar Typhimurium L-tryptophan + H2O
-
ir

Subunits

Subunits Comment Organism
heterodimer x-ray crystallography Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms Comment Organism
tryptophan synthase alpha2beta2 complex
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate the coenzyme for reactions catalyzed at the active site of the beta-subunit Salmonella enterica subsp. enterica serovar Typhimurium