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Literature summary for 4.2.1.2 extracted from

  • Singer, E.; Silas, Y.; Ben-Yehuda, S.; Pines, O.
    Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response (2017), eLife, 6, e30927 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
additional information enzyme colocalizes with the bacterial DNA Bacillus subtilis
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Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Expression

Organism Comment Expression
Bacillus subtilis expression is induced upon DNA damage up

General Information

General Information Comment Organism
physiological function enzyme is required for the DNA damage response. Fumarase-dependent intracellular signaling of the Bacillus subtilis DNA damage response is achieved via production of L-malic acid, which affects the translation of RecN, the first protein recruited to DNA damage sites. Absence of fumarase in the bacterial cell affects the levels and localization of the DNA damage response protein RecN. Expression in a mutant yeast strain can complement the lack of extra-mitochondrial fumarase with respect to sensitivity to DNA damage Bacillus subtilis