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Literature summary for 4.2.1.2 extracted from

  • Adam, J.; Yang, M.; Bauerschmidt, C.; Kitagawa, M.; OFlaherty, L.; Maheswaran, P.; Oezkan, G.; Sahgal, N.; Baban, D.; Kato, K.; Saito, K.; Iino, K.; Igarashi, K.; Stratford, M.; Pugh, C.; Tennant, D.A.; Ludwig, C.; Davies, B.; Ratcliffe, P.J.; El-Bahrawy, M.; Ashrafian, H.; Soga, T.; Pollard, P.J.
    A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia (2013), Cell Rep., 3, 1440-1448.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
fumarate hydratase
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 Homo sapiens

General Information

General Information Comment Organism
malfunction re-expression of cytosolic fumarate hydratase in FH1-deficient mice is critical for the suppression of renal cyst development and restoration of defects in the arginine biosynthesis pathway. fumarate hydratase-deficient cells exhibit a greater dependence on exogenous arginine than wild-type counterparts Homo sapiens