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Literature summary for 4.2.1.2 extracted from

  • Chen, Z.; Zhou, Q.; Ge, R.
    Inhibition of fumarase by bismuth(III): implications for the tricarboxylic acid cycle as a potential target of bismuth drugs in Helicobacter pylori (2012), Biometals, 25, 95-102.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene HP1325, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3) Helicobacter pylori

Inhibitors

Inhibitors Comment Organism Structure
Bi3+
-
Helicobacter pylori

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50900
-
x * 50900, about, sequence calculation, x * 43000-45000, recombinant enzyme, SDS-PAGE Helicobacter pylori
440000
-
oligomer 1, gel filtration Helicobacter pylori
600000
-
oligomer 2, gel filtration Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate Helicobacter pylori
-
fumarate + H2O
-
r

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
gene HP1325
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate
-
Helicobacter pylori fumarate + H2O
-
r

Subunits

Subunits Comment Organism
? x * 50900, about, sequence calculation, x * 43000-45000, recombinant enzyme, SDS-PAGE Helicobacter pylori

Synonyms

Synonyms Comment Organism
fumarase
-
Helicobacter pylori

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Helicobacter pylori

pI Value

Organism Comment pI Value Maximum pI Value
Helicobacter pylori sequence calculation
-
6.79