Literature summary for 4.2.1.2 extracted from

Tian, Z.; Liu, Y.; Usa, K.; Mladinov, D.; Fang, Y.; Ding, X.; Greene, A.S.; Cowley, A.W.; Liang, M.
Novel role of fumarate metabolism in dahl-salt sensitive hypertension (2009), Hypertension, 54, 255-260.

Search for more literature for 4.2.1.2

Cloned(Commentary)

Cloned (Comment)	Organism
entire protein-coding region of fumarase cDNA cloned from Dahl salt-sensitive, SS-13BN, and Brown Norway rats. PCR product inserted into the T-easy vector and propagated in competent Escherichia coli	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-
renal medulla	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	specific activity of fumarase is 2.9fold higher in SS-13BN rats	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-malate	-	Rattus norvegicus	fumarate + H2O	-	?

Synonyms

Synonyms	Comment	Organism
fumarase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	presence of lysine at amino acid position 481 in Dahl salt-sensitive rats and glutamic acid in Brown Norway and SS-13BN rats. The variation K481E likely contributes to the much higher specific activity of fumarase in SS-13BN rats. Total fumarase activity is significantly lower in the kidneys of Dahl salt-sensitive rats compared with SS-13BN rats, despite an apparent compensatory increase in fumarase abundance in Dahl salt-sensitive rats	Rattus norvegicus

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Release 2023.1 (January 2023)