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Literature summary for 4.2.1.18 extracted from

  • de Lima Stein, M.L.; Icimoto, M.Y.; de Castro Levatti, E.V.; Oliveira, V.; Straus, A.H.; Schenkman, S.
    Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei (2017), Mol. Biochem. Parasitol., 214, 36-46 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial matrix Trypanosoma brucei 5739
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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Trypanosoma brucei Lister 427
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-
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Source Tissue

Source Tissue Comment Organism Textmining
bloodstream form enzyme is expressed in both insect and mammalian bloodstream forms of Trypanosoma brucei Trypanosoma brucei
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Synonyms

Synonyms Comment Organism
3-MGCoA-H
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 Trypanosoma brucei
Tb427.10.4000
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 Trypanosoma brucei
Tb427.10.4000 gene locus Trypanosoma brucei

General Information

General Information Comment Organism
physiological function the depletion of 3-MGCoA-H by RNAi affects minimally the proliferation of both insect and mammalian bloodstream forms. An excess of leucine in the culture medium causes growth defects in cells depleted of 3-MGCoA-H, which can be reestablished by mevalonate. Procyclics depleted of the 3-MGCoA-H present reduced levels of synthesized steroids relative to cholesterol that is scavenged by the parasite Trypanosoma brucei