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Literature summary for 4.2.1.151 extracted from
- Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme (2013), J. Am. Chem. Soc., 135, 15318-15321.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli BL21 (DE3) | Thermus thermophilus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.162 | - |
chorismate | pH and temperature not specified in the publication | Thermus thermophilus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30500 | - |
x * 30500, SDS-PAGE | Thermus thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate | Thermus thermophilus | the enzyme is part of the futalosine pathway for menaquinone biosynthesis | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
| chorismate | Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | the enzyme is part of the futalosine pathway for menaquinone biosynthesis | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus thermophilus | Q5SK49 | - |
- |
| Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | Q5SK49 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Thermus thermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate | - |
Thermus thermophilus | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
| chorismate | the enzyme is part of the futalosine pathway for menaquinone biosynthesis | Thermus thermophilus | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
| chorismate | - |
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
| chorismate | the enzyme is part of the futalosine pathway for menaquinone biosynthesis | Thermus thermophilus HB8 / ATCC 27634 / DSM 579 | 3-[(1-carboxyvinyl)oxy]benzoate + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30500, SDS-PAGE | Thermus thermophilus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MqnA | - |
Thermus thermophilus |
| TTHA0803 | locus name | Thermus thermophilus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.27 | - |
chorismate | pH and temperature not specified in the publication | Thermus thermophilus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is part of the futalosine pathway for menaquinone biosynthesis | Thermus thermophilus |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7.8 | - |
chorismate | pH and temperature not specified in the publication | Thermus thermophilus | |
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Release 2023.1 (January 2023)
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