Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.146 extracted from

  • Kuivanen, J.; Mojzita, D.; Wang, Y.; Hilditch, S.; Penttilä, M.; Richard, P.; Wiebe, M.G.
    Engineering filamentous fungi for conversion of D-galacturonic acid to L-galactonic acid (2012), Appl. Environ. Microbiol., 78, 8676-8683.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.146

Application

Application Comment Organism
synthesis extracellular production of L-galactonate in gram quantities from D-galacturonic and polygalacturonic acids. DELTAgaaB strains produce L-galactonate at yields of 0.6 to 0.9 g per g of substrate consumed. Intracellular accumulation of L-galactonate suggests that export may be limiting. Deletion of the L-galactonate dehydratase from Aspergillus niger delays induction of D-galacturonate reductase and overexpression of the reductase improves initial production rates. Deletion of the L-galactonate dehydratase from Aspergillus niger also delays or prevents induction of the putative D-galacturonate transporter An14g04280. Aspergillus nigergaaB produces L-galactonate from polygalacturonate as efficiently as from the monomer Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
 gene name
-
Trichoderma reesei
-
-
-

General Information

General Information Comment Organism
malfunction DELTAgaaB strains produced L-galactonate at yields of 0.6 to 0.9 g per g of substrate consumed. Intracellular accumulation of L-galactonate suggests that export may be limiting. Deletion of the L-galactonate dehydratase from Aspergillus niger delays induction of D-galacturonate reductase. Deletion of the L-galactonate dehydratase from Aspergillus niger also delayes or prevents induction of the putative D-galacturonate transporter An14g04280 Aspergillus niger
malfunction Trichoderma reesei DELTAlgd1 strain produces L-galactonate at yields of 0.6 to 0.9 g per g of substrate consumed Trichoderma reesei