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Literature summary for 4.2.1.139 extracted from

  • Liu, Y.; Hassan, S.; Kidd, B.N.; Garg, G.; Mathesius, U.; Singh, K.B.; Anderson, J.P.
    Ethylene signaling is important for isoflavonoid-mediated resistance to Rhizoctonia solani in roots of Medicago truncatula (2017), Mol. Plant Microbe Interact., 30, 691-700 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the skl mutant of strain A17 shows no induction of the enzyme, or amounts of medicarpin or 7,4'-dihydroxyflavone, by ethylene, but accumulates isoprenoid precursors of the defense molecules, e.g. the precursor of medicarpin. Overexpression of the isoflavonoid pathway increases the resistance against root pathogen Rhizoctonia solani strain AG8. No compensation of the phenotype by medicarpin addition Medicago truncatula

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7,2'-dihydroxy-4'-methoxyisoflavanol Medicago truncatula
-
(-)-medicarpin + H2O
-
?
7,2'-dihydroxy-4'-methoxyisoflavanol Medicago truncatula A17
-
(-)-medicarpin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Medicago truncatula
-
-
-
Medicago truncatula A17
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
Medicago truncatula
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,2'-dihydroxy-4'-methoxyisoflavanol
-
Medicago truncatula (-)-medicarpin + H2O
-
?
7,2'-dihydroxy-4'-methoxyisoflavanol
-
Medicago truncatula A17 (-)-medicarpin + H2O
-
?

Expression

Organism Comment Expression
Medicago truncatula the enzyme expression is induced in roots by ethylene up

General Information

General Information Comment Organism
malfunction the ethylene-insensitive strain A17 mutant sickle (skl) with a point mutation in the EIN2 gene is highly susceptible to Rhizoctonia solani strain AG8 and shows no transcriptional response of the isoflavonoid-related genes. The skl mutant of strain A17 shows no induction of the amounts of medicarpin or 7,4'-dihydroxyflavone, by ethylene, but accumulates isoprenoid precursors of the defense molecules, e.g. the precursor of medicarpin. Overexpression of the isoflavonoid pathway increases the resistance against root pathogen Rhizoctonia solani strain AG8. No compensation of the phenotype by medicarpin addition Medicago truncatula
physiological function strain A17 shows accumulation of phytoalexin medicarpin, as well as of other isoflavonoid-related compounds like liquiritigenin, formononetin, and biochanin A. The strain is resistant against Rhizoctonia solani infection. Medicarpin is derived from the isoflavonoid-based biosynthesis pathway and involved in plant defense. Rhizoctonia solani strain AG8 infection induces the defense genes by production of ethylene. The enzyme is involved in ethylene-iduced plant defense against root pathogens Medicago truncatula