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Literature summary for 4.2.1.132 extracted from

  • Horinouchi, M.; Hayashi, T.; Koshino, H.; Kurita, T.; Kudo, T.
    Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441 (2005), Appl. Environ. Microbiol., 71, 5275-5281.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O Comamonas testosteroni 2-hydroxyhexa-2,4-dienoic acid is an intermediate of testosterone degradation 4-hydroxy-2-oxohexanoic acid
-
 ?
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O Comamonas testosteroni TA441 2-hydroxyhexa-2,4-dienoic acid is an intermediate of testosterone degradation 4-hydroxy-2-oxohexanoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Comamonas testosteroni
-
 formerly Pseudomonas testosteroni, gene tesE
-
Comamonas testosteroni TA441
-
 formerly Pseudomonas testosteroni, gene tesE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O 2-hydroxyhexa-2,4-dienoic acid is an intermediate of testosterone degradation Comamonas testosteroni 4-hydroxy-2-oxohexanoic acid
-
 ?
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O i.e. X5P-1, stable in enol form in methanol solution Comamonas testosteroni 4-hydroxy-2-oxohexanoic acid
-
 ?
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O 2-hydroxyhexa-2,4-dienoic acid is an intermediate of testosterone degradation Comamonas testosteroni TA441 4-hydroxy-2-oxohexanoic acid
-
 ?
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O i.e. X5P-1, stable in enol form in methanol solution Comamonas testosteroni TA441 4-hydroxy-2-oxohexanoic acid
-
 ?

Synonyms

Synonyms Comment Organism
TesE
-
 Comamonas testosteroni

General Information

General Information Comment Organism
metabolism 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes are involved in testosterone degradation in strain TA441. The organism utilizes testosterone via aromatization of the A ring Comamonas testosteroni