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Literature summary for 4.2.1.120 extracted from

  • Huber, H.; Gallenberger, M.; Jahn, U.; Eylert, E.; Berg, I.A.; Kockelkorn, D.; Eisenreich, W.; Fuchs, G.
    A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic archaeum Ignicoccus hospitalis (2008), Proc. Natl. Acad. Sci. USA, 105, 7851-7856.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxybutanoyl-CoA Ignicoccus hospitalis the enzyme is part of autotrophic CO2 fixation pathway in archaea (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?
4-hydroxybutanoyl-CoA Ignicoccus hospitalis DSM 18386 the enzyme is part of autotrophic CO2 fixation pathway in archaea (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?

Organism

Organism UniProt Comment Textmining
Ignicoccus hospitalis A8AA25
-
-
Ignicoccus hospitalis DSM 18386 A8AA25
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1
-
40°C, pH and temperature not specified in the publication Ignicoccus hospitalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxybutanoyl-CoA
-
Ignicoccus hospitalis (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?
4-hydroxybutanoyl-CoA the enzyme is part of autotrophic CO2 fixation pathway in archaea Ignicoccus hospitalis (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?
4-hydroxybutanoyl-CoA
-
Ignicoccus hospitalis DSM 18386 (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?
4-hydroxybutanoyl-CoA the enzyme is part of autotrophic CO2 fixation pathway in archaea Ignicoccus hospitalis DSM 18386 (E)-but-2-enoyl-CoA + H2O i.e. crotonyl-CoA ?

Synonyms

Synonyms Comment Organism
Igni_0595 locus name Ignicoccus hospitalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
assay at Ignicoccus hospitalis

General Information

General Information Comment Organism
physiological function the enzyme is part of autotrophic CO2 fixation pathway in archaea Ignicoccus hospitalis