Literature summary for 4.2.1.10 extracted from

Peon, A.; Robles, A.; Blanco, B.; Convertino, M.; Thompson, P.; Hawkins, A.R.; Caflisch, A.; Gonzalez-Bello, C.
Reducing the flexibility of type II dehydroquinase for inhibition a fragment-based approach and molecular dynamics study (2017), ChemMedChem, 12, 1512-1524 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-2-[5-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)pentyl]-2-hydroxybutanedioic acid	quinazolinedione derivative that disables the catalytic loop plasticity, compound forces the catalytic loop into an inappropriate arrangement for catalysis by strong interactions with the catalytic tyrosine and by expelling the essential arginine out of the active site	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	Q48255	-	-
Helicobacter pylori 26695	Q48255	-	-

Synonyms

Synonyms	Comment	Organism
DHQ2	-	Helicobacter pylori

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Release 2023.1 (January 2023)