Application | Comment | Organism |
---|---|---|
medicine | dehydroquinate synthase is a target for microbial agents, anti-parasitic agents and herbicides | Helicobacter pylori |
Cloned (Comment) | Organism |
---|---|
into the pQE30 vector for expression in Escherichia coli JM109 cells | Helicobacter pylori |
Crystallization (Comment) | Organism |
---|---|
the crystal structure of dehydroquinate synthase complexed with NAD is determined at 2.4 A resolution | Helicobacter pylori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbaphosphonate | - |
Helicobacter pylori | |
HTS 11955 | - |
Helicobacter pylori | |
RH00573 | - |
Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-deoxy-D-arabino-heptulosonate 7-phosphate | Helicobacter pylori | - |
3-dehydroquinate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Purification (Comment) | Organism |
---|---|
purified by immobilized nickel-ion chromatography | Helicobacter pylori |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-deoxy-D-arabino-heptulosonate 7-phosphate | - |
Helicobacter pylori | 3-dehydroquinate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dehydroquinate synthase | - |
Helicobacter pylori |
DHQS | - |
Helicobacter pylori |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
enzymatic assay | Helicobacter pylori |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
enzymatic assay | Helicobacter pylori |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Helicobacter pylori |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000008 | - |
carbaphosphonate | - |
Helicobacter pylori |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.061 | - |
- |
Helicobacter pylori | HTS 11955 | |
0.0845 | - |
- |
Helicobacter pylori | RH00573 |