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Literature summary for 4.2.1.10 extracted from

  • Toscano, M.D.; Payne, R.J.; Chiba, A.; Kerbarh, O.; Abell, C.
    Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism (2007), ChemMedChem, 2, 101-112.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid
-
Mycobacterium tuberculosis
(1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid
-
Streptomyces coelicolor
(1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid
-
Mycobacterium tuberculosis
(1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid
-
Streptomyces coelicolor
(3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid
-
Mycobacterium tuberculosis
(3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid
-
Streptomyces coelicolor
(3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid
-
Mycobacterium tuberculosis
(3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid
-
Streptomyces coelicolor
3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid
-
Salmonella enterica subsp. enterica serovar Typhi
3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid
-
Streptomyces coelicolor
4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid
-
Salmonella enterica subsp. enterica serovar Typhi
4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid
-
Streptomyces coelicolor
4-hydroxy-4-methyl-pent-2-enedioic acid
-
Salmonella enterica subsp. enterica serovar Typhi
4-hydroxy-4-methyl-pent-2-enedioic acid
-
Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Salmonella enterica subsp. enterica serovar Typhi
-
-
-
Streptomyces coelicolor
-
-
-

Synonyms

Synonyms Comment Organism
Type I dehydroquinase
-
Salmonella enterica subsp. enterica serovar Typhi
Type II dehydroquinase
-
Mycobacterium tuberculosis
Type II dehydroquinase
-
Streptomyces coelicolor

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000032
-
(3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Streptomyces coelicolor
0.00024
-
(3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid pH 7.0 Streptomyces coelicolor
0.00094
-
(3R,5R,6R)-3,5,6-trihydroxycyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Mycobacterium tuberculosis
0.016
-
(3R,5R,6R)-3-carbamoyl-3,5,6-trihydroxycyclohex-1-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
0.025
-
(1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid pH 7.0 Streptomyces coelicolor
0.027
-
(1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
0.029
-
(1R,4R,5R)-3-(tert-butylcarbamoyl)-1,4,5-trihydroxycyclohex-2-enecarboxylic acid pH 7.0 Streptomyces coelicolor
0.105
-
(1R,4R,5R)-3-(2-carboxy-vinyl)-1,4,5-trihydroxy-cyclohex-2-enecarboxylic acid pH 7.0 Mycobacterium tuberculosis
0.47
-
4-hydroxy-4-methyl-pent-2-enedioic acid pH 7.0 Streptomyces coelicolor
0.65
-
4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi
0.76
-
3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Streptomyces coelicolor
0.99
-
4-hydroxy-4-methyl-pent-2-enedioic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi
1
-
4-hydroxy-2-hydroxymethyl-4-methyl-pent-2-enedioic acid pH 7.0 Streptomyces coelicolor
1.7
-
3-hydroxy-cyclohex-1-ene-1,3-dicarboxylic acid pH 7.0 Salmonella enterica subsp. enterica serovar Typhi