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Literature summary for 4.2.1.1 extracted from

  • Demirdag, R.; Comakli, V.; Kuzu, M.; Yerlikaya, E.; Sentuerk, M.
    Purification and characterization of carbonic anhydrase from Agri Balik Lake trout gill (Salmo trutta labrax) and effects of sulfonamides on enzyme activity (2015), J. Biochem. Mol. Toxicol., 29, 123-128 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-bromo-benzene sulfonamide
-
Salmo labrax
2-bromobenzene-1-sulfonamide
-
Salmo labrax
4-amino-6-chloro-1-3 benzenedisulfonamide
-
Salmo labrax
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Salmo labrax
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
-
Salmo labrax
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
-
Salmo labrax
4-amino-N-carbamimidoylbenzene-1-sulfonamide
-
Salmo labrax
4-chlorobenzene sulfonamide
-
Salmo labrax
4-chlorobenzene-1-sulfonamide
-
Salmo labrax
4-methylbenzene-1-sulfonamide
-
Salmo labrax
6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
-
Salmo labrax
acetazolamide
-
Salmo labrax
brinzolamide
-
Salmo labrax
diclofenamide
-
Salmo labrax
dorzolamide
-
Salmo labrax
mafenide
-
Salmo labrax
metazolamide
-
Salmo labrax
additional information strongest inhibitors of enzyme CA are aromatic or heteroaromatic sulfonamides Salmo labrax
p-toluenesulfonamide
-
Salmo labrax
Sulfadiazine
-
Salmo labrax
Sulfaguanidine
-
Salmo labrax
sulfamethazine
-
Salmo labrax

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of 4-nitrophenyl acetate hydrolysis reaction Salmo labrax

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required, metalloenzyme Salmo labrax

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO2 + H2O Salmo labrax
-
H2CO3
-
r
H2CO3 Salmo labrax
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Salmo labrax
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme 303.9fold from gills by L-tyrosine-sulfanilamide affinity chromatography Salmo labrax

Source Tissue

Source Tissue Comment Organism Textmining
gill
-
Salmo labrax
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
purified native enzyme, specific activity 4130.4 EU/mg of protein Salmo labrax

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Salmo labrax H2CO3
-
r
H2CO3
-
Salmo labrax CO2 + H2O
-
r
additional information enzyme activity assay using the enzyme's esterase activity with 4-nitrophenyl acetate as substrate Salmo labrax ?
-
?

Subunits

Subunits Comment Organism
? x * 29900, SDS-PAGE Salmo labrax

Synonyms

Synonyms Comment Organism
fCA
-
Salmo labrax

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
Salmo labrax

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Salmo labrax

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics of CA isozymes, overview Salmo labrax
0.0075
-
4-methylbenzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.0216
-
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.0303
-
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.0674
-
2-bromobenzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.0683
-
6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.0736
-
4-amino-6-chlorobenzene-1,3-disulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.08275
-
4-chlorobenzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.09125
-
4-amino-N-carbamimidoylbenzene-1-sulfonamide pH 7.4, 25°C, inhibition of 4-nitrophenyl acetate hydrolysis activity Salmo labrax
0.10875
-
brinzolamide pH 7.4, 25°C Salmo labrax