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Literature summary for 4.2.1.1 extracted from

  • Sumi, K.R.; Kim, S.C.; Natarajan, S.; Choi, K.S.; Choi, M.R.; Kim, H.T.; Park, J.I.; Nou, I.S.; Gilmour, K.M.; Kho, K.H.
    Molecular cloning and characterization of secretory carbonic anhydrase VI in pufferfish (Takifugu rubripes) (2018), Gene, 640, 57-65 .
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
isozyme carbonic anhydrase 6, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis and tree, quantitative real-time PCR and quantitative/semiquantitative RT-PCR expression analysis Takifugu rubripes

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the isozyme VI is secreted Takifugu rubripes
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required, metalloenzyme Takifugu rubripes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Takifugu rubripes
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Takifugu rubripes A0A2D1CFJ9
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein isozyme CA VI contains three potential N-linked glycosylation sites Takifugu rubripes
additional information two cysteine residues, Cys28 and Cys209, that are likely to form one disulfide bond, are present in pufferfish CA VI Takifugu rubripes

Source Tissue

Source Tissue Comment Organism Textmining
liver the pufferfish CA VI is highly expressed in liver tissue Takifugu rubripes
-
additional information quantitative and semiquantitative RT-PCR expression analysis and in situ hybridization Takifugu rubripes
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Takifugu rubripes CO2 + H2O
-
 r

Subunits

Subunits Comment Organism
More three-dimensional homology structure modeling of carbonic anhydrase VI, overview Takifugu rubripes

Synonyms

Synonyms Comment Organism
CA VI
-
 Takifugu rubripes
carbonic anhydrase 6
-
 Takifugu rubripes
carbonic anhydrase VI
-
 Takifugu rubripes
secretory carbonic anhydrase VI
-
 Takifugu rubripes

General Information

General Information Comment Organism
evolution comparisons of putative active site residues between CA II and CA VI from humans and several fishes Takifugu rubripes
additional information homology modeling of puffer CA VI is performed using the crystal structure of human carbonic anhydrase XIV as a template structure Takifugu rubripes
physiological function pufferfish CA VI is an extracellular secretory protein Takifugu rubripes