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Literature summary for 4.2.1.1 extracted from

  • Chiaramonte, N.; Bua, S.; Ferraroni, M.; Nocentini, A.; Bonardi, A.; Bartolucci, G.; Durante, M.; Lucarini, L.; Chiapponi, D.; Dei, S.; Manetti, D.; Teodori, E.; Gratteri, P.; Masini, E.; Supuran, C.T.; Romanelli, M.N.
    2-Benzylpiperazine a new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents (2018), Eur. J. Med. Chem., 151, 363-375 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
purified enzyme in complex with inhibitors (S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide and (S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide, sitting drop vapor diffusion method, mixing of 0.002 ml of 10 mg/ml protein in 20 mM Tris-HCl, pH 9.0, with 0.002 ml of a solution of 28-31% PEG 4000, 0.2 M sodium acetate, 0.1 M Tris, pH 8.5-9.0 and equilibration against the same solution at 23°C, fifteen days, afterwards the crystals are soaked in 5 mM inhibitor solutions for 3 days, X-ray diffraction structure determination and analysis at 1.5-1.6 A resolution Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one
-
Homo sapiens
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide
-
Homo sapiens
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one
-
Homo sapiens
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide
-
Homo sapiens
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
Homo sapiens
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
Homo sapiens
acetazolamide AAZ, a sulfonamide inhibitor; AAZ, a sulfonamide inhibitor; AAZ, a sulfonamide inhibitor Homo sapiens
additional information 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens P00915
-
-
Homo sapiens P00918
-
-
Homo sapiens P22748
-
-
Homo sapiens Q16790
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
Homo sapiens CO2 + H2O
-
r
additional information pH-based enzyme activity detection Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CA1
-
Homo sapiens
CA2
-
Homo sapiens
CA4
-
Homo sapiens
CA9
-
Homo sapiens
hCA I
-
Homo sapiens
HCA II
-
Homo sapiens
hCA IV
-
Homo sapiens
hCA IX
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000017
-
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000002
-
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000002
-
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000023
-
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000023
-
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000026
-
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000029
-
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000029
-
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000033
-
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000036
-
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000036
-
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000036
-
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000039
-
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.000004
-
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000046
-
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000048
-
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000051
-
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000054
-
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000054
-
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000056
-
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000006
-
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000006
-
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000061
-
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000062
-
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000066
-
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000068
-
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000007
-
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000075
-
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000076
-
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000076
-
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000076
-
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000077
-
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000078
-
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000078
-
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000079
-
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000079
-
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000081
-
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000083
-
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000087
-
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000087
-
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000088
-
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000096
-
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.000015
-
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000154
-
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000019
-
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000218
-
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000221
-
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000279
-
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000029
-
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000293
-
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000295
-
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000306
-
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000307
-
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000316
-
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000032
-
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000323
-
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000334
-
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000377
-
(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000389
-
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000443
-
(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.000046
-
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000494
-
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000516
-
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000525
-
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000539
-
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000556
-
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000572
-
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000593
-
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000607
-
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0000607
-
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000613
-
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000622
-
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000668
-
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000669
-
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000068
-
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000725
-
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000733
-
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000744
-
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0000754
-
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000793
-
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000797
-
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0000828
-
(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.000083
-
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0000834
-
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0000837
-
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0000889
-
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0000927
-
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000093
-
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0000951
-
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000104
-
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0001334
-
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000139
-
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000146
-
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.000161
-
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000166
-
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.00017
-
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000176
-
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.000177
-
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000181
-
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000186
-
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.000191
-
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000198
-
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000205
-
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000225
-
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000227
-
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0002273
-
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000232
-
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000245
-
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.000245
-
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.00025
-
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0002645
-
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0003278
-
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.0003303
-
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0003425
-
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0003586
-
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA II, pH 9.0, 40°C Homo sapiens
0.00036
-
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.000371
-
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IV, pH 9.0, 40°C Homo sapiens
0.0003802
-
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0004185
-
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.0004219
-
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0004557
-
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.0005426
-
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.0005686
-
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA I, pH 9.0, 40°C Homo sapiens
0.000707
-
(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme, pH 9.0, 40°C Homo sapiens
0.001207
-
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001207
-
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001432
-
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001442
-
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.00152
-
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001589
-
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001659
-
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001716
-
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001718
-
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.001811
-
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.002626
-
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens
0.002639
-
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide inhibition of isozyme hCA IX, pH 9.0, 40°C Homo sapiens

General Information

General Information Comment Organism
additional information the polypeptide segment Val131-Asp136 in CA IV arranges in an extended loop conformation rich of charged residues extending to the outside Homo sapiens