Crystallization (Comment) | Organism |
---|---|
purified enzyme in complex with inhibitors (S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide and (S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide, sitting drop vapor diffusion method, mixing of 0.002 ml of 10 mg/ml protein in 20 mM Tris-HCl, pH 9.0, with 0.002 ml of a solution of 28-31% PEG 4000, 0.2 M sodium acetate, 0.1 M Tris, pH 8.5-9.0 and equilibration against the same solution at 23°C, fifteen days, afterwards the crystals are soaked in 5 mM inhibitor solutions for 3 days, X-ray diffraction structure determination and analysis at 1.5-1.6 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | - |
Homo sapiens | |
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | - |
Homo sapiens | |
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | - |
Homo sapiens | |
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | - |
Homo sapiens | |
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | - |
Homo sapiens | |
acetazolamide | AAZ, a sulfonamide inhibitor; AAZ, a sulfonamide inhibitor; AAZ, a sulfonamide inhibitor | Homo sapiens | |
additional information | 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview; 2-benzylpiperazine is a scaffold for potent human carbonic anhydrase inhibitors, compounds synthesis, enzyme inhibition, and enantioselectivity, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00915 | - |
- |
Homo sapiens | P00918 | - |
- |
Homo sapiens | P22748 | - |
- |
Homo sapiens | Q16790 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
additional information | pH-based enzyme activity detection | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CA1 | - |
Homo sapiens |
CA2 | - |
Homo sapiens |
CA4 | - |
Homo sapiens |
CA9 | - |
Homo sapiens |
hCA I | - |
Homo sapiens |
HCA II | - |
Homo sapiens |
hCA IV | - |
Homo sapiens |
hCA IX | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000017 | - |
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000002 | - |
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000002 | - |
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000023 | - |
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000023 | - |
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000026 | - |
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000029 | - |
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000029 | - |
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000033 | - |
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000036 | - |
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000036 | - |
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000036 | - |
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000039 | - |
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.000004 | - |
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000046 | - |
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000048 | - |
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000051 | - |
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000054 | - |
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000054 | - |
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000056 | - |
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000006 | - |
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000006 | - |
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000061 | - |
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000062 | - |
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000066 | - |
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000068 | - |
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000007 | - |
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000075 | - |
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000076 | - |
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000076 | - |
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000076 | - |
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000077 | - |
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000078 | - |
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000078 | - |
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000079 | - |
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000079 | - |
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000081 | - |
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000083 | - |
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000087 | - |
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000087 | - |
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000088 | - |
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000096 | - |
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.000015 | - |
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000154 | - |
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000019 | - |
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000218 | - |
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000221 | - |
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000279 | - |
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000029 | - |
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000293 | - |
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000295 | - |
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000306 | - |
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000307 | - |
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000316 | - |
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000032 | - |
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000323 | - |
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000334 | - |
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000377 | - |
(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000389 | - |
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000443 | - |
(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.000046 | - |
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000494 | - |
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000516 | - |
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000525 | - |
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000539 | - |
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000556 | - |
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000572 | - |
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000593 | - |
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000607 | - |
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0000607 | - |
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000613 | - |
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000622 | - |
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000668 | - |
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000669 | - |
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000068 | - |
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000725 | - |
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000733 | - |
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000744 | - |
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0000754 | - |
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000793 | - |
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000797 | - |
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0000828 | - |
(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.000083 | - |
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0000834 | - |
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0000837 | - |
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0000889 | - |
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0000927 | - |
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000093 | - |
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0000951 | - |
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000104 | - |
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0001334 | - |
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000139 | - |
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000146 | - |
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.000161 | - |
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000166 | - |
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.00017 | - |
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000176 | - |
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.000177 | - |
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000181 | - |
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000186 | - |
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.000191 | - |
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000198 | - |
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000205 | - |
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000225 | - |
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000227 | - |
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0002273 | - |
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000232 | - |
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000245 | - |
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.000245 | - |
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.00025 | - |
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0002645 | - |
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0003278 | - |
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.0003303 | - |
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0003425 | - |
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0003586 | - |
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA II, pH 9.0, 40°C | Homo sapiens | |
0.00036 | - |
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.000371 | - |
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IV, pH 9.0, 40°C | Homo sapiens | |
0.0003802 | - |
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0004185 | - |
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.0004219 | - |
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0004557 | - |
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.0005426 | - |
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.0005686 | - |
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA I, pH 9.0, 40°C | Homo sapiens | |
0.000707 | - |
(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme, pH 9.0, 40°C | Homo sapiens | |
0.001207 | - |
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001207 | - |
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001432 | - |
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001442 | - |
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.00152 | - |
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001589 | - |
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001659 | - |
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001716 | - |
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001718 | - |
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.001811 | - |
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.002626 | - |
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens | |
0.002639 | - |
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide | inhibition of isozyme hCA IX, pH 9.0, 40°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the polypeptide segment Val131-Asp136 in CA IV arranges in an extended loop conformation rich of charged residues extending to the outside | Homo sapiens |