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Literature summary for 4.2.1.1 extracted from

  • Del Prete, S.; Vullo, D.; De Luca, V.; Carginale, V.; Scozzafava, A.; Supuran, C.T.; Capasso, C.
    A highly catalytically active alpha-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules (2013), Bioorg. Med. Chem. Lett., 23, 4067-4071.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide
-
 Porphyromonas gingivalis
Br-
-
 Porphyromonas gingivalis
Cl-
-
 Porphyromonas gingivalis
CN-
-
 Porphyromonas gingivalis
CNO-
-
 Porphyromonas gingivalis
CO32-
-
 Porphyromonas gingivalis
CS32-
-
 Porphyromonas gingivalis
Et2NCS2-
-
 Porphyromonas gingivalis
F-
-
 Porphyromonas gingivalis
H2NSO2NH2
-
 Porphyromonas gingivalis
H2NSO3H
-
 Porphyromonas gingivalis
HCO3-
-
 Porphyromonas gingivalis
HS-
-
 Porphyromonas gingivalis
N3-
-
 Porphyromonas gingivalis
Ph-AsO3H2
-
 Porphyromonas gingivalis
Ph-B(OH)2
-
 Porphyromonas gingivalis
ReO4-
-
 Porphyromonas gingivalis
SCN-
-
 Porphyromonas gingivalis
SeCN-
-
 Porphyromonas gingivalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32300
-
 calculated from cDNA Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Porphyromonas gingivalis H2CO3
-
 ?

Synonyms

Synonyms Comment Organism
PgiCA
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
 assay at Porphyromonas gingivalis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
410000
-
 CO2 pH 8.3, 20°C Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000324
-
 acetazolamide pH 8.3, 20°C Porphyromonas gingivalis
0.004
-
 Et2NCS2- pH 8.3, 20°C Porphyromonas gingivalis
0.0092
-
 H2NSO2NH2 pH 8.3, 20°C Porphyromonas gingivalis
0.0098
-
 Ph-B(OH)2 pH 8.3, 20°C Porphyromonas gingivalis
0.041
-
 CN- pH 8.3, 20°C Porphyromonas gingivalis
0.073
-
 N3- pH 8.3, 20°C Porphyromonas gingivalis
0.09
-
 Ph-AsO3H2 pH 8.3, 20°C Porphyromonas gingivalis
0.092
-
 HS- pH 8.3, 20°C Porphyromonas gingivalis
0.093
-
 SCN- pH 8.3, 20°C Porphyromonas gingivalis
0.093
-
 H2NSO3H pH 8.3, 20°C Porphyromonas gingivalis
0.096
-
 HCO3- pH 8.3, 20°C Porphyromonas gingivalis
0.097
-
 CS32- pH 8.3, 20°C Porphyromonas gingivalis
0.71
-
 CNO- pH 8.3, 20°C Porphyromonas gingivalis
0.89
-
 CO32- pH 8.3, 20°C Porphyromonas gingivalis
0.91
-
 SeCN- pH 8.3, 20°C Porphyromonas gingivalis
0.92
-
 Br- pH 8.3, 20°C Porphyromonas gingivalis
0.93
-
 ReO4- pH 8.3, 20°C Porphyromonas gingivalis
0.94
-
 Cl- pH 8.3, 20°C Porphyromonas gingivalis
0.95
-
 F- pH 8.3, 20°C Porphyromonas gingivalis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
540000
-
 CO2 pH 8.3, 20°C Porphyromonas gingivalis