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Literature summary for 4.2.1.1 extracted from

  • Dave, K.; Scozzafava, A.; Vullo, D.; Supuran, C.T.; Ilies, M.A.
    Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII (2011), Org. Biomol. Chem., 9, 2790-2800.
    View publication on PubMed
Search for more literature for 4.2.1.1

Activating Compound

Activating Compound Comment Organism Structure
1-[2-(1H-imidazol-4-yl)-ethyl]-2,3,4,6-tetramethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,4,6-trimethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,4-dimethyl-6-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-methylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-methylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-methylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-methylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-3,5-(nonane-1,9-diyl)pyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-4-phenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diphenyl-4-methylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-dimethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-diphenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-dimethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-diphenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-methyl-4,6-diphenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl -4,6 -dimethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl-4,6-diphenylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-dimethylpyridinium hexafluorophosphate
-
 Homo sapiens
1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-diphenylpyridinium hexafluorophosphate
-
 Homo sapiens
4-[2-(4-dimethylaminophenyl)-vinyl]-1-[2-(1H-imidazol-4-yl)ethyl]-2,6-di-isopropylpyridinium hexafluorophosphate
-
 Homo sapiens
histamine
-
 Homo sapiens
additional information activating effects on the cytosolic isozymes hCA I, hCA II, and hCA VII, competitive steady-state activation kinetics of the pyridinium histamine derivatives, KA values, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic isozymes hCA I, hCA II, and hCA VII Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ active site bound and essential for catalysis, metalloenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
carbonic anhydrase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens