Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate | - |
Homo sapiens | |
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-(benzyloxy)-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-adamantylethoxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-butoxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-ethoxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-hydroxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-methoxy-2H-chromen-2-one | - |
Homo sapiens | |
6-acetyl-7-propoxy-2H-chromen-2-one | - |
Homo sapiens | |
7-ethoxy-8-propanoyl-2H-chromen-2-one | - |
Homo sapiens | |
7-hydroxy-6-propanoyl-2H-chromen-2-one | - |
Homo sapiens | |
7-hydroxy-8-propanoyl-2H-chromen-2-one | - |
Homo sapiens | |
7-methoxy-8-propanoyl-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-(benzyloxy)-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-butoxy-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-ethoxy-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-hydroxy-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-methoxy-2H-chromen-2-one | - |
Homo sapiens | |
8-acetyl-7-propoxy-2H-chromen-2-one | - |
Homo sapiens | |
8-propanoyl-7-propoxy-2H-chromen-2-one | - |
Homo sapiens | |
coumarin | - |
Homo sapiens | |
additional information | synthesis of two series of disubstituted coumarins incorporating ether and acetyl/propionyl moieties in positions 6,7 and 7,8 of the heterocyclic ring. The compounds are very weak or ineffective as inhibitors of the housekeeping, offtarget isozymes CA I and CA II. The 6,7-disubstituted series show ineffective inhibition also for the transmembrane tumor-associated isoforms CA IX and XII, whereas the corresponding isomeric 7,8-disubstituted coumarins show nanomolar/subnanomolar inhibition of CA IX/XII, overview. No inhibition by 12 and 13 | Homo sapiens | |
umbelliferone | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes hCA I, hCA II, hCA IX, and hCA XII | - |
Synonyms | Comment | Organism |
---|---|---|
carbonic anhydrase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000098 | - |
8-acetyl-7-propoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000001 | - |
8-acetyl-7-ethoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000088 | - |
8-acetyl-7-butoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000224 | - |
8-acetyl-7-(benzyloxy)-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000263 | - |
7-methoxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000315 | - |
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000332 | - |
7-ethoxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000378 | - |
7-methoxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000384 | - |
8-propanoyl-7-propoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000467 | - |
7-ethoxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000486 | - |
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000502 | - |
8-propanoyl-7-propoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000545 | - |
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000567 | - |
8-acetyl-7-propoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000582 | - |
7-hydroxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000059 | - |
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000609 | - |
8-acetyl-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000612 | - |
8-acetyl-7-butoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000617 | - |
7-hydroxy-8-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000619 | - |
8-acetyl-7-hydroxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000639 | - |
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000708 | - |
8-acetyl-7-ethoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000723 | - |
8-acetyl-7-(benzyloxy)-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000073 | - |
8-acetyl-7-hydroxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000078 | - |
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0000783 | - |
8-acetyl-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0001 | - |
coumarin | inhibition of isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0001 | - |
coumarin | inhibition of isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000482 | - |
umbelliferone | inhibition of isozyme hCA II, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.000754 | - |
umbelliferone | inhibition of isozyme hCA I, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0031 | - |
coumarin | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00654 | - |
6-acetyl-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0074 | - |
6-acetyl-7-ethoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00758 | - |
6-acetyl-7-propoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0078 | - |
6-acetyl-7-methoxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.008015 | - |
7-hydroxy-6-propanoyl-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.00803 | - |
6-acetyl-7-hydroxy-2H-chromen-2-one | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0092 | - |
coumarin | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0584 | - |
umbelliferone | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.0777 | - |
6-acetyl-7-adamantylethoxy-2H-chromen-2-one | inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.1 | - |
umbelliferone | inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication | Homo sapiens |