Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-pyrimidin-4-yl-sulfanilamide | best inhibitor | Mycobacterium tuberculosis | |
2-aminobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
3-(4-sulfamoylphenyl)propanoic acid | - |
Mycobacterium tuberculosis | |
4-(2-aminoethyl)benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-(2-hydroxyethyl)benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-(aminomethyl)benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-(hydroxymethyl)benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-3-bromobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-3-chlorobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-3-fluorobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-3-iodobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-6-chlorobenzene-1,3-disulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-Aminobenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-methylbenzenesulfonamide | - |
Mycobacterium tuberculosis | |
4-sulfamoylbenzoic acid | - |
Mycobacterium tuberculosis | |
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide | - |
Mycobacterium tuberculosis | |
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | - |
Mycobacterium tuberculosis | |
5-amino-1,3,4-thiadiazole-2-sulfonamide | - |
Mycobacterium tuberculosis | |
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | - |
Mycobacterium tuberculosis | |
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Mycobacterium tuberculosis | |
acetazolamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
benzolamide | - |
Mycobacterium tuberculosis | |
brinzolamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
celecoxib | - |
Mycobacterium tuberculosis | |
dichlorophenamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
dorzolamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
ethoxzolamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
indisulam | - |
Mycobacterium tuberculosis | |
methazolamide | effective, submicromolar inhibition | Mycobacterium tuberculosis | |
saccharin | - |
Mycobacterium tuberculosis | |
sulpiride | - |
Mycobacterium tuberculosis | |
sulthiame | - |
Mycobacterium tuberculosis | |
topiramate | - |
Mycobacterium tuberculosis | |
valdecoxib | - |
Mycobacterium tuberculosis | |
zonisamide | effective, submicromolar inhibition | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Mycobacterium tuberculosis | H2CO3 | - |
r | |
CO2 + H2O | - |
Mycobacterium tuberculosis H37Rv | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA 3 | - |
Mycobacterium tuberculosis |
carbonic anhydrase | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
430000 | - |
CO2 | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000091 | - |
2-amino-pyrimidin-4-yl-sulfanilamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000091 | - |
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000104 | - |
acetazolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000137 | - |
dorzolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00017 | - |
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000186 | - |
4-amino-3-bromobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000201 | - |
brinzolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000208 | - |
zonisamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000338 | - |
benzolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000562 | - |
methazolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000594 | - |
ethoxzolamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000611 | - |
dichlorophenamide | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000612 | - |
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00075 | - |
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000853 | - |
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.000905 | - |
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00151 | - |
4-amino-3-chlorobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00172 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00221 | - |
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00235 | - |
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00251 | - |
4-(2-hydroxyethyl)benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00302 | - |
topiramate | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0031 | - |
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00342 | - |
4-(2-aminoethyl)benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00492 | - |
4-methylbenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00551 | - |
4-(2-hydroxyethyl)benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00581 | - |
4-amino-3-iodobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00624 | - |
2-aminobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00672 | - |
sulthiame | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00702 | - |
4-methylbenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00711 | - |
4-Aminobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00715 | - |
saccharin | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00732 | - |
4-amino-3-bromobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00733 | - |
4-(aminomethyl)benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0074 | - |
4-sulfamoylbenzoic acid | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00748 | - |
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00752 | - |
4-amino-3-chlorobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0076 | - |
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00763 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00771 | - |
4-amino-3-iodobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00776 | - |
celecoxib | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00781 | - |
valdecoxib | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00782 | - |
4-(hydroxymethyl)benzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00783 | - |
3-(4-sulfamoylphenyl)propanoic acid | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00784 | - |
indisulam | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0079 | - |
4-amino-3-fluorobenzenesulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00792 | - |
sulpiride | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00792 | - |
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00793 | - |
3-(4-sulfamoylphenyl)propanoic acid | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0081 | - |
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00821 | - |
4-sulfamoylbenzoic acid | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00869 | - |
4-(aminomethyl)benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00874 | - |
4-amino-3-fluorobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00923 | - |
2-aminobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00956 | - |
4-(2-aminoethyl)benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00956 | - |
4-(hydroxymethyl)benzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.00984 | - |
4-Aminobenzenesulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.01154 | - |
5-amino-1,3,4-thiadiazole-2-sulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.01265 | - |
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | isoform CA 1, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis | |
0.0217 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | isoform CA 3, at 20°C and pH 8.3, in 20 mM Tris-HCl buffer and 20 mM NaCl | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
40000 | - |
CO2 | at 20°C, pH 8.3, in 20 mM Tris-HCl and 20 mM NaCl | Mycobacterium tuberculosis |