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Literature summary for 4.2.1.1 extracted from

  • Abdo, M.R.; Vullo, D.; Saada, M.C.; Montero, J.L.; Scozzafava, A.; Winum, J.Y.; Supuran, C.T.
    Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido L-histidine derivatives (2009), Bioorg. Med. Chem. Lett., 19, 2440-2443.
    View publication on PubMed
Search for more literature for 4.2.1.1

Activating Compound

Activating Compound Comment Organism Structure
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-(naphthalen-2-ylsulfonyl)propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-iodophenyl)sulfonyl]propanehydrazide hydrochloride submicromolar activator of isoform CA II, but shows much higher affinities for isoforms CA I and IX Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methoxyphenyl)sulfonyl]propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide hydrochloride effective CA IX activator Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-nitrophenyl)sulfonyl]propanehydrazide hydrochloride effective CA IX activator Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(pentafluorophenyl)sulfonyl]propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[[4-(trifluoromethyl)phenyl]sulfonyl]propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride effective CA IX activator Homo sapiens
(2S)-2-amino-N'-[(4-chlorophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-N'-[(4-cyanophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride
-
 Homo sapiens
(2S)-2-amino-N'-[(4-fluorophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride effective CA IX activator Homo sapiens
(2S)-2-amino-N'-[(4-tert-butylphenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride
-
 Homo sapiens
L-His
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoforms CA I and CA II Homo sapiens 5829
-
membrane isoform CA IX is a transmembrane enzyme Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO2 + H2O Homo sapiens
-
 H2CO3
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P00918
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
CA I isozyme Homo sapiens
CA II isozyme Homo sapiens
CA IX isozyme Homo sapiens
carbonic anhydrase
-
 Homo sapiens