Literature summary for 4.2.1.1 extracted from

Innocenti, A.; Zimmerman, S.A.; Scozzafava, A.; Ferry, J.G.; Supuran, C.T.
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines (2008), Bioorg. Med. Chem. Lett., 18, 6194-6198.

Activating Compound

Activating Compound	Comment	Organism
1-(2-aminoethyl)-piperazine	-	Methanothermobacter thermautotrophicus
1-(2-aminoethyl)-piperazine	effectively activates Zn-gamma-class carbonic anhydrase	Methanosarcina thermophila
2-pyridyl-methylamine	-	Methanothermobacter thermautotrophicus
2-pyridyl-methylamine	-	Methanosarcina thermophila
2-pyridylmethylamine	-	Methanothermobacter thermautotrophicus
2-pyridylmethylamine	effectively activates Zn-gamma-class carbonic anhydrase	Methanosarcina thermophila
4-(2-aminoethyl)-morpholine	-	Methanothermobacter thermautotrophicus
4-(2-aminoethyl)-morpholine	-	Methanosarcina thermophila
4-amino-L-phenylalanine	-	Methanothermobacter thermautotrophicus
4-amino-L-phenylalanine	-	Methanosarcina thermophila
D-3,4-dihydroxyphenylalanine	-	Methanothermobacter thermautotrophicus
D-3,4-dihydroxyphenylalanine	-	Methanosarcina thermophila
D-His	-	Methanothermobacter thermautotrophicus
D-His	-	Methanosarcina thermophila
D-Phe	-	Methanosarcina thermophila
D-Phe	effective beta-class carbonic anhydrase activator	Methanothermobacter thermautotrophicus
D-Trp	-	Methanothermobacter thermautotrophicus
D-Trp	-	Methanosarcina thermophila
dopamine	-	Methanothermobacter thermautotrophicus
dopamine	-	Methanosarcina thermophila
histamine	-	Methanothermobacter thermautotrophicus
histamine	-	Methanosarcina thermophila
L-3,4-dihydroxyphenylalanine	-	Methanothermobacter thermautotrophicus
L-3,4-dihydroxyphenylalanine	-	Methanosarcina thermophila
L-adrenaline	-	Methanothermobacter thermautotrophicus
L-adrenaline	-	Methanosarcina thermophila
L-His	-	Methanothermobacter thermautotrophicus
L-His	-	Methanosarcina thermophila
L-Phe	-	Methanothermobacter thermautotrophicus
L-Phe	-	Methanosarcina thermophila
L-Trp	-	Methanothermobacter thermautotrophicus
L-Trp	-	Methanosarcina thermophila
L-Tyr	-	Methanosarcina thermophila
L-Tyr	effective beta-class carbonic anhydrase activator	Methanothermobacter thermautotrophicus
serotonin	-	Methanothermobacter thermautotrophicus
serotonin	-	Methanosarcina thermophila

Organism

Organism	UniProt	Comment	Textmining
Methanosarcina thermophila	-	-	-
Methanothermobacter thermautotrophicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Methanothermobacter thermautotrophicus	H2CO3	-	r
CO2 + H2O	-	Methanosarcina thermophila	H2CO3	-	r

Synonyms

Synonyms	Comment	Organism
beta-class carbonic anhydrase	-	Methanothermobacter thermautotrophicus
Cab	-	Methanothermobacter thermautotrophicus
Cam	-	Methanosarcina thermophila
gamma-class carbonic anhydrase	-	Methanosarcina thermophila