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Literature summary for 4.2.1.1 extracted from

  • Hilvo, M.; Supuran, C.T.; Parkkila, S.
    Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV (2007), Curr. Top. Med. Chem., 7, 893-899.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of the extracellular domain of murine CA XIV solved at 2.8 A resolution, and the enzyme-acetazolamide complex at 2.9 A resolution Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-aminoethyl-benzenesulfonamide carbonic anhydrase XIII Mus musculus
acetazolamide carbonic anhydrase XIII Mus musculus
azide carbonic anhydrase XIII Mus musculus
bisulfate weak, carbonic anhydrase XIII Mus musculus
Br- weak, carbonic anhydrase XIII Mus musculus
Carbonate carbonic anhydrase XIII Mus musculus
Cyanate carbonic anhydrase XIII Mus musculus
cyanide carbonic anhydrase XIII Mus musculus
dichlorophenamide carbonic anhydrase XIII Mus musculus
dorzolamide carbonic anhydrase XIII Mus musculus
F- carbonic anhydrase XIII Mus musculus
homosulfanilamide carbonic anhydrase XIII Mus musculus
hydrogen sulfide carbonic anhydrase XIII Mus musculus
I- carbonic anhydrase XIII Mus musculus
methazolamide carbonic anhydrase XIII Mus musculus
additional information overview Homo sapiens
additional information overview Mus musculus
nitrate weak, carbonic anhydrase XIII Mus musculus
nitrite weak, carbonic anhydrase XIII Mus musculus
orthanilamide carbonic anhydrase XIII Mus musculus
phenylarsonic acid carbonic anhydrase XIII Mus musculus
phenylboronic acid carbonic anhydrase XIII Mus musculus
sulfamic acid weak, carbonic anhydrase XIII Mus musculus
thiocyanate carbonic anhydrase XIII Mus musculus
valdecoxib carbonic anhydrase XIII Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
axon carbonic anhydrase XIV Mus musculus 30424
-
axon carbonic anhydrase XIV Homo sapiens 30424
-
cytosol carbonic anhydrase XIII Homo sapiens 5829
-
cytosol carbonic anhydrase XIII Mus musculus 5829
-
extracellular carbonic anhydrase XIV Mus musculus
-
-
extracellular carbonic anhydrase XIV Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9ULX7
-
-
Mus musculus
-
-
-
Mus musculus Q9D6N1
-
-
no activity in Homo sapiens
-
carbonic anhydrase XV is not expressed in humans, non-processed pseudogene
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylated Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain carbonic anhydrase XIII Mus musculus
-
brain carbonic anhydrase XIV Mus musculus
-
brain carbonic anhydrase XIV Homo sapiens
-
brain neuronal membrane, carbonic anhydrase XIV Mus musculus
-
brain neuronal membrane, carbonic anhydrase XIV Homo sapiens
-
cerebellum carbonic anhydrase XIII Mus musculus
-
colon carbonic anhydrase XIII Mus musculus
-
colorectal mucosa neoplastic, carbonic anhydrase XIII Homo sapiens
-
enterocyte in every segment of the gut, carbonic anhydrase XIII Homo sapiens
-
epithelial cell of the duct, carbonic anhydrase XIII Homo sapiens
-
gastric mucosa low expression, carbonic anhydrase XIII Homo sapiens
-
gastrointestinal tract CA XIII is found mainly in surface epithelial cells of the body and antrum segments. carbonic anhydrase XIII Homo sapiens
-
glial cell carbonic anhydrase XIV Mus musculus
-
gut enterocytes, carbonic anhydrase XIII Homo sapiens
-
heart carbonic anhydrase XIV Mus musculus
-
heart carbonic anhydrase XIV Homo sapiens
-
hepatocyte carbonic anhydrase XIV Mus musculus
-
ileum carbonic anhydrase XIII Homo sapiens
-
jejunum carbonic anhydrase XIII Homo sapiens
-
kidney carbonic anhydrase XIV Homo sapiens
-
kidney expressed in cortical and medullary ducts, carbonic anhydrase XIII Mus musculus
-
kidney in both renal cortex and medulla the strongest expression is confined to the collecting ducts and weak expression can be found in the glomerulus, carbonic anhydrase XIII Homo sapiens
-
kidney renal cortex has higher expression than renal medulla Mus musculus
-
kidney strongest expression of CA XIV is detected in the cortex region, where it is restricted to the proximal tubules of S1 and S2 segments, carbonic anhydrase XIV Mus musculus
-
liver carbonic anhydrase XIV Mus musculus
-
liver carbonic anhydrase XIV Homo sapiens
-
lung carbonic anhydrase XIV Mus musculus
-
lung carbonic anhydrase XIV Homo sapiens
-
additional information no expression in testis Mus musculus
-
oligodendrocyte carbonic anhydrase XIII Mus musculus
-
retina CA XIV is highly expressed on both the basal and apical surfaces of the pigmented epithelial cells of the retina, carbonic anhydrase XIV Mus musculus
-
semen carbonic anhydrase XIII Homo sapiens
-
serous acinar cell carbonic anhydrase XIII Homo sapiens
-
skeletal muscle carbonic anhydrase XIV Mus musculus
-
skeletal muscle carbonic anhydrase XIV Homo sapiens
-
submandibular gland carbonic anhydrase XIII Homo sapiens
-
telencephalon carbonic anhydrase XIII Mus musculus
-
uterine cervix carbonic anhydrase XIII Homo sapiens
-
uterine endometrium carbonic anhydrase XIII Homo sapiens
-

Synonyms

Synonyms Comment Organism
CA XIII
-
Homo sapiens
CA XIII
-
Mus musculus
CA XIV
-
Mus musculus
CA XIV
-
Homo sapiens
Ca XV
-
Mus musculus
carbonic anhydrase XIII
-
Homo sapiens
carbonic anhydrase XIII
-
Mus musculus
carbonic anhydrase XIV
-
Mus musculus
carbonic anhydrase XIV
-
Homo sapiens
carbonic anhydrase XV
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000425
-
valdecoxib carbonic anhydrase XIII Mus musculus