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Literature summary for 4.2.1.1 extracted from

  • Guezel, O.; Temperini, C.; Innocenti, A.; Scozzafava, A.; Salman, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies (2008), Bioorg. Med. Chem. Lett., 18, 152-158.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the hCA/2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide adduct Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain Homo sapiens
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme mCA XIII Mus musculus
brinzolamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain Homo sapiens
brinzolamide isoenzyme mCA XIII Mus musculus
dorzolamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain Homo sapiens
dorzolamide isoenzyme mCA XIII Mus musculus
ethoxzolamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain Homo sapiens
ethoxzolamide isoenzyme mCA XIII Mus musculus
zonisamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV catalytic domain Homo sapiens
zonisamide isoenzyme mCA XIII Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O14939
-
-
Homo sapiens P00915
-
-
Homo sapiens P00918
-
-
Homo sapiens P07451
-
-
Homo sapiens P22748
-
-
Homo sapiens P23280
-
-
Homo sapiens P35218
-
-
Homo sapiens P43166
-
-
Homo sapiens Q16790
-
-
Homo sapiens Q9ULX7
-
-
Homo sapiens Q9Y2D0
-
-
Mus musculus Q9D6N1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Homo sapiens H2CO3
-
?
CO2 + H2O
-
Mus musculus H2CO3
-
?

Synonyms

Synonyms Comment Organism
hCA I
-
Homo sapiens
HCA II
-
Homo sapiens
hCA III
-
Homo sapiens
hCA IV
-
Homo sapiens
hCA IX
-
Homo sapiens
hCA VA
-
Homo sapiens
hCA VB
-
Homo sapiens
hCA VI
-
Homo sapiens
hCA VII
-
Homo sapiens
hCA XII
-
Homo sapiens
hCA XIV catalytic domain
-
Homo sapiens
mCA XIII
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000008
-
ethoxzolamide isoenzyme hCA VII Homo sapiens
0.0000028
-
brinzolamide isoenzyme hCA VII catalytic domain Homo sapiens
0.000003
-
brinzolamide isoenzyme hCA II Homo sapiens
0.000003
-
brinzolamide isoenzyme hCA XII catalytic domain Homo sapiens
0.0000035
-
dorzolamide isoenzyme hCA VII Homo sapiens
0.0000035
-
dorzolamide isoenzyme hCA XII Homo sapiens
0.0000051
-
zonisamide isoenzyme hCA IX catalytic domain Homo sapiens
0.0000072
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA II Homo sapiens
0.0000075
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA I Homo sapiens
0.000009
-
dorzolamide isoenzyme hCA II Homo sapiens
0.000009
-
brinzolamide isoenzyme hCA VI catalytic domain Homo sapiens
0.00001
-
dorzolamide isoenzyme hCA VI Homo sapiens
0.00001
-
brinzolamide isoenzyme mCA XIII catalytic domain Mus musculus
0.000018
-
dorzolamide isoenzyme mCA XIII Mus musculus
0.000019
-
ethoxzolamide isoenzyme hCA VB Homo sapiens
0.00002
-
zonisamide isoenzyme hCA VA catalytic domain Homo sapiens
0.000022
-
ethoxzolamide isoenzyme hCA XII Homo sapiens
0.000024
-
brinzolamide isoenzyme hCA XIV catalytic domain catalytic domain Homo sapiens
0.000025
-
ethoxzolamide isoenzyme hCA I Homo sapiens
0.000025
-
ethoxzolamide isoenzyme hCA VA Homo sapiens
0.000025
-
ethoxzolamide isoenzyme hCA XIV catalytic domain Homo sapiens
0.000027
-
dorzolamide isoenzyme hCA XIV catalytic domain Homo sapiens
0.00003
-
brinzolamide isoenzyme hCA VB catalytic domain Homo sapiens
0.000033
-
dorzolamide isoenzyme hCA VB Homo sapiens
0.000034
-
ethoxzolamide isoenzyme hCA IX Homo sapiens
0.000035
-
zonisamide isoenzyme hCA II Homo sapiens
0.000037
-
brinzolamide isoenzyme hCA IX catalytic domain Homo sapiens
0.000042
-
dorzolamide isoenzyme hCA VA Homo sapiens
0.000043
-
ethoxzolamide isoenzyme hCA VI Homo sapiens
0.000048
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA XIV catalytic domain Homo sapiens
0.00005
-
brinzolamide isoenzyme hCA VA catalytic domain Homo sapiens
0.00005
-
ethoxzolamide isoenzyme mCA XIII Mus musculus
0.000052
-
dorzolamide isoenzyme hCA IX Homo sapiens
0.000056
-
zonisamide isoenzyme hCA I Homo sapiens
0.00008
-
ethoxzolamide isoenzyme hCA II Homo sapiens
0.000089
-
zonisamide isoenzyme hCA VI catalytic domain Homo sapiens
0.000089
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA VII Homo sapiens
0.000093
-
ethoxzolamide isoenzyme hCA IV Homo sapiens
0.000102
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA IX Homo sapiens
0.00011
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA XII Homo sapiens
0.000117
-
zonisamide isoenzyme hCA VII catalytic domain Homo sapiens
0.00043
-
zonisamide isoenzyme mCA XIII catalytic domain Mus musculus
0.0011
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA VA Homo sapiens
0.0011
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA VB Homo sapiens
0.002633
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme mCA XIII Mus musculus
0.00265
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA VI Homo sapiens
0.00395
-
brinzolamide isoenzyme hCA IV catalytic domain Homo sapiens
0.00525
-
zonisamide isoenzyme hCA XIV catalytic domain catalytic domain Homo sapiens
0.006033
-
zonisamide isoenzyme hCA VB catalytic domain Homo sapiens
0.0085
-
dorzolamide isoenzyme hCA IV Homo sapiens
0.00859
-
zonisamide isoenzyme hCA IV catalytic domain Homo sapiens
0.009
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA IV Homo sapiens
0.011
-
zonisamide isoenzyme hCA XII catalytic domain Homo sapiens
0.045
-
brinzolamide isoenzyme hCA I Homo sapiens
0.05
-
dorzolamide isoenzyme hCA I Homo sapiens
0.11
-
brinzolamide isoenzyme hCA III Homo sapiens
0.77
-
dorzolamide isoenzyme hCA III Homo sapiens
1.1
-
ethoxzolamide isoenzyme hCA III Homo sapiens
1.4
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide isoenzyme hCA III Homo sapiens
2.2
-
zonisamide isoenzyme hCA III Homo sapiens