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Literature summary for 4.2.1.1 extracted from

  • Fenesan, I.; Popescu, R.; Scozzafava, A.; Crucin, V.; Mateiciuc, E.; Bauer, R.; Ilies, M.A.; Supuran, C.T.
    Carbonic anhydrase inhibitors; phosphoryl-sulfonamides-a new class of high affinity inhibitors of isozymes I and II (2000), J. Enzyme Inhib., 15, 297-310.
    View publication on PubMed

Application

Application Comment Organism
pharmacology extensively investigated enzyme as a target for drug design Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
CA I and CA II cDNAs expressed in Escherichia coli BL21 (DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ArSO2-NHPO3H2
-
Homo sapiens
N,N'-biphosphoryl-4,5-dichloro-1,3-benzenesulfonamide
-
Homo sapiens
N-phosphoryl-4-carboxy-benzenesulfonamide
-
Homo sapiens
N-phosphoryl-6-nitro-benzothiazole-2-sulfonamide
-
Homo sapiens
N-phosphoryl-benzothiazole -2-sulfonamide
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
Homo sapiens 4-nitrophenol + acetate
-
?
H2CO3
-
Homo sapiens CO2 + H2O
-
r

Synonyms

Synonyms Comment Organism
CA I
-
Homo sapiens
CA II
-
Homo sapiens
carbonic anhydrase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
N-phosphoryl-6-nitro-benzothiazole-2-sulfonamide pH 7.4, 25°C, hCA II Homo sapiens
0.000003
-
N-phosphoryl-benzothiazole-2-sulfonamide pH 7.4, 25°C, hCA II Homo sapiens
0.000007
-
N-phosphoryl-6-nitro-benzothiazole-2-sulfonamide pH 7.4, 25°C, hCA I Homo sapiens
0.00001
-
N-phosphoryl-benzothiazole-2-sulfonamide pH 7.4, 25°C, hCA I Homo sapiens
0.000015
-
N,N'-biphosphoryl-4,5-dichloro-1,3-benzenesulfonamide pH 7.4, 25°C, hCA II Homo sapiens
0.000045
-
N-phosphoryl-4-carboxy-benzenesulfonamide pH 7.4, 25°C, hCA II Homo sapiens
0.000052
-
N,N'-biphosphoryl-4,5-dichloro-1,3-benzenesulfonamide pH 7.4, 25°C, hCA I Homo sapiens
0.000125
-
N-phosphoryl-4-carboxy-benzenesulfonamide pH 7.4, 25°C, hCA I Homo sapiens