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Literature summary for 4.2.1.1 extracted from

  • Elleby, B.; Sjoeblom, B.; Lindskog, S.
    Changing the efficiency and specificity of the esterase activity of human carbonic anhydrase II by site-specific mutagenesis (1999), Eur. J. Biochem., 262, 516-521.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A65L site-specific mutagenesis, enhancement of activity with all substrates, about 5fold increase in activity with 4-nitrophenyl acetate Homo sapiens
A65L/T200G site-specific mutagenesis, 5fold increase in activity with 4-nitrophenylacetate Homo sapiens
A65L/T200R site-specific mutagenesis, 4fold increase in activity with 4-nitrophenylacetate Homo sapiens
L198A site-specific mutagenesis, 5fold decrease in activity with 4-nitrophenylacetate Homo sapiens
T200A site-specific mutagenesis, enhancement of activity with all substrates, about 2fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200D site-specific mutagenesis, 93fold decrease in activity with 4-nitrophenylacetate Homo sapiens
T200G site-specific mutagenesis, 3fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200H site-specific mutagenesis, enhancement of activity with all substrates, 2fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200I site-specific mutagenesis, enhancement of activity with all substrates, 1.5fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200K site-specific mutagenesis, enhancement of activity with all substrates, 1.3fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200N site-specific mutagenesis, enhancement of activity with all substrates Homo sapiens
T200R site-specific mutagenesis, enhancement of activity with all substrates, 7fold increase in activity with 4-nitrophenyl acetate Homo sapiens
T200S site-specific mutagenesis, 3fold increase in activity with 4-nitrophenyl acetate, decrease in activity with all other substrates Homo sapiens
T200V site-specific mutagenesis, decrease in activity with all substrates Homo sapiens
V121A site-specific mutagenesis, 4fold decrease in activity with 4-nitrophenylacetate Homo sapiens
V143A site-specific mutagenesis, 2fold decrease in activity with 4-nitrophenylacetate Homo sapiens
V143G site-specific mutagenesis, 6fold decrease in activity with 4-nitrophenylacetate Homo sapiens
V207A site-specific mutagenesis, 1.5fold decrease in activity with 4-nitrophenylacetate Homo sapiens
Y7F site-specific mutagenesis, enhancement of activity with all substrates Homo sapiens
Y7F/T200G site-specific mutagenesis, 1.5fold increase in activity with 4-nitrophenylacetate Homo sapiens
Y7F/T200R site-specific mutagenesis, 7.5fold increase in activity with 4-nitrophenylacetate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-Nitrophenol product inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
CO2 + H2O
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-nitrophenyl acetate + H2O
-
Homo sapiens 2-nitrophenol + acetate
-
?
3-nitrophenyl acetate + H2O
-
Homo sapiens 3-nitrophenol + acetate
-
?
4-nitrophenyl acetate + H2O
-
Homo sapiens 4-nitrophenol + acetate
-
?
4-nitrophenyl propionate + H2O
-
Homo sapiens 4-nitrophenol + propionate
-
?
H2CO3
-
Homo sapiens CO2 + H2O
-
r

Synonyms

Synonyms Comment Organism
human carbonic anhydrase II
-
Homo sapiens