Literature summary for 4.2.1.1 extracted from

Baird, T.T.; Waheed, A.; Okuyama, T.; Sly, W.S.; Fierke, C.A.
Catalysis and inhibition of human carbonic anhydrase IV (1997), Biochemistry, 36, 2669-2678.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Br-	below 20 mM, activates	Homo sapiens
Cl-	below 20 mM, activates	Homo sapiens
phosphate	below 20 mM, activates	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Sulfonamides	affinity of carbonic anhydrase IV for sulfonamides is decreased up to 65fold compared to carbonic anhydrase II	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
8	-	CO2	carbonic anhydrase II	Homo sapiens
22	-	CO2	carbonic anhydrase IV	Homo sapiens
26	-	HCO3-	carbonic anhydrase IV	Homo sapiens
37	-	HCO3-	carbonic anhydrase II	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	bound	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	carbonic anhydrase IV	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	phospholipid anchor may be acting both as an extracellular tether and as a protein activator	Homo sapiens

Reaction

Reaction	Comment	Organism	Reaction ID
H2CO3 = CO2 + H2O	mechanism	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	carbonic anhydrase IV	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Homo sapiens	H2CO3	-	r

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Homo sapiens
18300	-	CO2	pH-independent turnover	Homo sapiens

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Release 2023.1 (January 2023)