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Literature summary for 4.1.99.25 extracted from
- Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom (2005), Angew. Chem. Int. Ed. Engl., 44, 7045-7048 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| heterologous expression of DNA extracted directly from environmental samples (environmental DNA, eDNA) in Escherichia coli | uncultured organism |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + D-ribulose 5-phosphate | uncultured organism | the enzyme catalyzes the biosynthesis of the isocyanide-containing antibiotic(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate (i.e. L-tryptophan isonitrile) | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| uncultured organism | Q108L3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + D-ribulose 5-phosphate | the enzyme catalyzes the biosynthesis of the isocyanide-containing antibiotic(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate (i.e. L-tryptophan isonitrile) | uncultured organism | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | - |
? | |
| L-tryptophan + D-ribulose 5-phosphate | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate i.e. L-tryptophan isonitrile, hydroxyacetone i.e. 1-hydroxypropan-2-one | uncultured organism | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| isnA | - |
uncultured organism |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the biosynthesis of the isocyanide-containing antibiotic(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate | uncultured organism |
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Release 2023.1 (January 2023)
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