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Literature summary for 4.1.99.22 extracted from

  • Lees, N.S.; Hänzelmann, P.; Hernandez, H.L.; Subramanian, S.; Schindelin, H.; Johnson, M.K.; Hoffman, B.M.
    ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications (2009), J. Am. Chem. Soc., 131, 9184-9185.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
MoaC protein the S-adenosyl-L-methionine-dependent enzyme MoaA, in concert with MoaC, catalyzes the first step of molybdenum cofactor biosynthesis, the conversion of 5'-GTP into precursor Z Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
C24S/C28S/C31S the mutant does not contain the catalytic S-adenosyl-L-methionine-binding cluster I Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
iron-sulfur centre guanine N1 binds to [4Fe-4S] cluster II Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Staphylococcus aureus
-
 cyclic pyranopterin phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Staphylococcus aureus cyclic pyranopterin phosphate + diphosphate
-
 ?
GTP the S-adenosyl-L-methionine-dependent enzyme MoaA, in concert with MoaC, catalyzes the first step of molybdenum cofactor biosynthesis, the conversion of 5'-GTP into precursor Z Staphylococcus aureus cyclic pyranopterin phosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
MoaA
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine the S-adenosyl-L-methionine-dependent enzyme MoaA, in concert with MoaC, catalyzes the first step of molybdenum cofactor biosynthesis, the conversion of 5'-GTP into precursor Z Staphylococcus aureus