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Literature summary for 4.1.99.2 extracted from
- Paraffin as oxygen vector modulates tyrosine phenol lyase production by Citrobacter freundii MTCC 2424 (2013), Acta Microbiol. Immunol. Hung., 60, 145-154.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | major applications of tyrosine phenol lyase in the production of L-tyrosine and L-DOPA. Tyrosine phenol lyase also has the ability to modify and synthesize natural and non-natural amino acids | Citrobacter freundii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-3-4 dihydroxyphenylalanine + H2O | Citrobacter freundii | L-dopa | catechol + pyruvate + NH3 | - |
r |  |
| L-3-4 dihydroxyphenylalanine + H2O | Citrobacter freundii MTCC 2424 | L-dopa | catechol + pyruvate + NH3 | - |
r | |
| L-tyrosine + H2O | Citrobacter freundii | alpha-beta elimination | phenol + pyruvate + NH3 | - |
r | |
| L-tyrosine + H2O | Citrobacter freundii MTCC 2424 | alpha-beta elimination | phenol + pyruvate + NH3 | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Citrobacter freundii | - |
- |
- |
| Citrobacter freundii MTCC 2424 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | optimization and evaluation of cultivation conditions, overview | Citrobacter freundii | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-3-4 dihydroxyphenylalanine + H2O | L-dopa | Citrobacter freundii | catechol + pyruvate + NH3 | - |
r | |
| L-3-4 dihydroxyphenylalanine + H2O | L-dopa | Citrobacter freundii MTCC 2424 | catechol + pyruvate + NH3 | - |
r | |
| L-tyrosine + H2O | alpha-beta elimination | Citrobacter freundii | phenol + pyruvate + NH3 | - |
r | |
| L-tyrosine + H2O | alpha-beta elimination | Citrobacter freundii MTCC 2424 | phenol + pyruvate + NH3 | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPL | - |
Citrobacter freundii |
| tyrosine phenol lyase | - |
Citrobacter freundii |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Citrobacter freundii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Citrobacter freundii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | dependent on | Citrobacter freundii | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Citrobacter freundii | L-tyrosine induces the enzyme, liquid paraffin as oxygen vector has a stimulatory effect on the enzyme synthesis | up |
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