Literature summary for 4.1.99.2 extracted from

Koyanagi, T.; Katayama, T.; Suzuki, H.; Onishi, A.; Yokozeki, K.; Kumagai, H.
Hyperproduction of 3,4-dihydroxyphenyl-L-alanine (L-Dopa) using Erwinia herbicola cells carrying a mutant transcriptional regulator TyrR (2009), Biosci. Biotechnol. Biochem., 73, 1221-1223.

Search for more literature for 4.1.99.2

Organism

Organism	UniProt	Comment	Textmining
Pantoea agglomerans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
catechol + pyruvate + NH3	-	Pantoea agglomerans	3,4-dihydroxyphenyl-L-alanine	-	r
L-tyrosine + H2O	-	Pantoea agglomerans	phenol + pyruvate + NH3	-	r

Synonyms

Synonyms	Comment	Organism
TPL	-	Pantoea agglomerans
tyrosine phenol-lyase	-	Pantoea agglomerans

Expression

Organism	Comment	Expression
Pantoea agglomerans	TyrR is the transcriptional activator of Tpl. Amino acid substitutions of TyrR, V67A, Y72C and E201G in the N-terminal domain, N324D in the central domain, A503T in the C-terminal domain, all enhance Tpl expression	up

General Information

General Information	Comment	Organism
physiological function	hyper-3,4-dihydroxyphenyl-L-alanine-producing strain by a mutant TyrR, an activator of tpl, whereby highest productivity is obtained for the strain grown under non-induced conditions, which is 30fold higher than that obtained for tyrosine-induced wild-type cells	Pantoea agglomerans

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Release 2023.1 (January 2023)