Literature summary for 4.1.99.2 extracted from

Demidkina, T.V.; Myagkikh, I.V.; Azhayev, A.V.
Transamination catalysed by tyrosine phenol-lyase from Citrobacter intermedius (1987), Eur. J. Biochem., 170, 311-316.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-Ala	competitive	Citrobacter intermedius
L-m-Tyr	competitive	Citrobacter intermedius
L-Phe	competitive	Citrobacter intermedius

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.24	-	Tyr	beta-elimination	Citrobacter intermedius
0.94	-	L-m-Tyr	transamination	Citrobacter intermedius
4.15	-	Phe	beta-elimination	Citrobacter intermedius
6.1	-	Ala	beta-elimination	Citrobacter intermedius
34	-	Ser	beta-elimination	Citrobacter intermedius
51	-	Ser	transamination	Citrobacter intermedius

Organism

Organism	UniProt	Comment	Textmining
Citrobacter intermedius	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala + pyridoxal phosphate	-	Citrobacter intermedius	pyridoxamine phosphate + keto acid	-	ir
L-m-Tyr + pyridoxal phosphate	-	Citrobacter intermedius	pyridoxamine phosphate + keto acid	-	ir
L-Phe + pyridoxal phosphate	-	Citrobacter intermedius	pyridoxamine phosphate + keto acid	-	ir
L-Ser + pyridoxal phosphate	-	Citrobacter intermedius	pyridoxamine phosphate + keto acid	-	ir
Ser + H2O	-	Citrobacter intermedius	? + pyruvate + NH3	-	?
Tyr + H2O	L-Tyr	Citrobacter intermedius	phenol + pyruvate + NH3	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0008	-	Phe	beta-elimination	Citrobacter intermedius
0.001	-	Ser	transamination	Citrobacter intermedius
0.00153	-	Ala	beta-elimination	Citrobacter intermedius
0.00268	-	L-m-Tyr	transamination	Citrobacter intermedius
0.012	-	Ser	beta-elimination	Citrobacter intermedius
0.2	-	Tyr	beta-elimination	Citrobacter intermedius

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Release 2023.1 (January 2023)