Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.99.13 extracted from

  • Walter, D.; Boswell, M.; Volk de Garcia, S.; Walter, S.; Breitenfeldt, E.; Boswell, W.; Walter, R.
    Characterization and differential expression of CPD and 6-4 DNA photolyases in Xiphophorus species and interspecies hybrids (2014), Comp. Biochem. Physiol. C, 163, 77-85 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.99.13

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, quantitative real-time PCR enzyme expression analysis Xiphophorus maculatus
DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, quantitative real-time PCR enzyme expression analysis Xiphophorus couchianus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6-4) photoproduct (in DNA) Xiphophorus maculatus
-
 2 pyrimidine residues (in DNA)
-
 ?
(6-4) photoproduct (in DNA) Xiphophorus couchianus
-
 2 pyrimidine residues (in DNA)
-
 ?
(6-4) photoproduct (in DNA) Xiphophorus maculatus Jp 163 B
-
 2 pyrimidine residues (in DNA)
-
 ?

Organism

Organism UniProt Comment Textmining
Xiphophorus couchianus
-
 and F1 interspecies hybrids made by crossing these two parental lines, i.e. Xiphophorus maculatus Jp 163 B × Xiphophorus couchianus
-
Xiphophorus maculatus
-
 and F1 interspecies hybrids made by crossing these two parental lines, i.e. Xiphophorus maculatus Jp 163 B × Xiphophorus couchianus
-
Xiphophorus maculatus Jp 163 B
-
 and F1 interspecies hybrids made by crossing these two parental lines, i.e. Xiphophorus maculatus Jp 163 B × Xiphophorus couchianus
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Xiphophorus maculatus
-
brain
-
 Xiphophorus couchianus
-
eye
-
 Xiphophorus maculatus
-
eye
-
 Xiphophorus couchianus
-
gill
-
 Xiphophorus maculatus
-
gill
-
 Xiphophorus couchianus
-
heart
-
 Xiphophorus maculatus
-
heart
-
 Xiphophorus couchianus
-
liver
-
 Xiphophorus maculatus
-
liver
-
 Xiphophorus couchianus
-
additional information tissue expression pattern, overview. The expression of 6-4 photolyase in F1 interspecies hybrids appears to be about 3-4fold above the parental line expression in the skin and eyes. In the brain and gill, the F1 interspecies hybrid 6-4 photolyase expression is similar to that of Xiphophorus couchianus, and both the F1 and Xiphophorus couchianus exhibit a greater than 5fold higher basal expression in the heart compared to Xiphophorus maculatus. The 6-4 photolyase becomes dramatically dysregulated in testis compared to either parent exhibiting substantial upregulated basal expression (over 30fold compared to Xiphophoruscouchianus and over 50fold for Xiphophorus maculatus). Liver shows much reduced 6-4 basal expression Xiphophorus maculatus
-
additional information tissue expression pattern, overview. The expression of 6-4 photolyase in F1 interspecies hybrids appears to be about 3-4fold above the parental line expression in the skin and eyes. In the brain and gill, the F1 interspecies hybrid 6-4 photolyase expression is similar to that of Xiphophorus couchianus, and both the F1 and Xiphophorus couchianus exhibit a greater than 5fold higher basal expression in the heart compared to Xiphophorus maculatus. The 6-4 photolyase becomes dramatically dysregulated in testis compared to either parent exhibiting substantial upregulated basal expression (over 30fold compared to Xiphophoruscouchianus and over 50fold for Xiphophorus maculatus). Liver shows much reduced 6-4 basal expression Xiphophorus couchianus
-
skin
-
 Xiphophorus maculatus
-
skin
-
 Xiphophorus couchianus
-
testis testes exhibit very high basal expression values in the F1 interspecies hybrid for photolyase 6-4 about 100fold higher than liver Xiphophorus maculatus
-
testis testes exhibit very high basal expression values in the F1 interspecies hybrid for photolyase 6-4 about 100fold higher than liver Xiphophorus couchianus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6-4) photoproduct (in DNA)
-
 Xiphophorus maculatus 2 pyrimidine residues (in DNA)
-
 ?
(6-4) photoproduct (in DNA)
-
 Xiphophorus couchianus 2 pyrimidine residues (in DNA)
-
 ?
(6-4) photoproduct (in DNA)
-
 Xiphophorus maculatus Jp 163 B 2 pyrimidine residues (in DNA)
-
 ?

Synonyms

Synonyms Comment Organism
6-4 DNA photolyase
-
 Xiphophorus maculatus
6-4 DNA photolyase
-
 Xiphophorus couchianus
6-4 photolyase
-
 Xiphophorus maculatus
6-4 photolyase
-
 Xiphophorus couchianus

Expression

Organism Comment Expression
Xiphophorus maculatus photolyase gene expression patterns before and after exposure to fluorescent light in Xiphophorus maculatus, Xiphophorus couchianus, and for F1 interspecies hybrids produced from crossing these two parental lines (Xiphophorus maculatus Jp 163 B × Xiphophorus couchianus) up
Xiphophorus couchianus photolyase gene expression patterns before and after exposure to fluorescent light in Xiphophorus maculatus, Xiphophorus couchianus, and for F1 interspecies hybrids produced from crossing these two parental lines (Xiphophorus maculatus Jp 163 B × Xiphophorus couchianus) up

General Information

General Information Comment Organism
physiological function UVB-induced DNA lesions in Xiphophorus fishes are thought to primarily be repaired via light dependent CPD and 6-4PP specific photolyases, cf. EC 4.1.99.3 Xiphophorus maculatus
physiological function UVB-induced DNA lesions in Xiphophorus fishes are thought to primarily be repaired via light dependent CPD and 6-4PP specific photolyases, cf. EC 4.1.99.3 Xiphophorus couchianus